Cortesina G, De Stefani A, Giovarelli M, Barioglio M G, Cavallo G P, Jemma C, Forni G
Department of Otolaryngology, Medical School, University of Turin, Italy.
Cancer. 1988 Dec 15;62(12):2482-5. doi: 10.1002/1097-0142(19881215)62:12<2482::aid-cncr2820621205>3.0.co;2-9.
Ten patients with recurrent squamous cell carcinoma of the head and neck received daily injections of interleukin-2 (IL-2) from the Jurkat T-cell line purified by high pressure liquid chromatography for 10 days. Two hundred units of IL-2 in 0.5 ml were injected 1.5 cm from the insertion of the sternocleidomastoid muscle on the mastoid. When possible, courses were repeated at 45-day intervals. IL-2 was ineffective in two patients who had already undergone functional or radical neck dissection. By contrast, in six patients with contralateral or bilateral cervical lymph nodes, complete or partial disappearance of the tumor was observed. The injections were occasionally followed by moderate local swelling and lymph node pain, but no systemic disturbances.
10例复发性头颈部鳞状细胞癌患者接受了经高压液相色谱法纯化的来自Jurkat T细胞系的白细胞介素-2（IL-2）每日注射，共注射10天。将0.5 ml含200单位IL-2的溶液在距胸锁乳突肌在乳突处的附着点1.5 cm处注射。如有可能，疗程每隔45天重复一次。2例已经接受功能性或根治性颈清扫术的患者，IL-2治疗无效。相比之下，6例有对侧或双侧颈部淋巴结转移的患者，观察到肿瘤完全或部分消失。注射后偶尔出现中度局部肿胀和淋巴结疼痛，但无全身不适。
