Philip Frost Dept of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA.
Dept. of Dermatology, San Gallicano Dermatological Institute, Rome, Italy.
Int J Clin Pract. 2020 Dec;74 Suppl 187:e13603. doi: 10.1111/ijcp.13603.
Urea is an emollient widely used in clinical dermatology to moisturise and protect the skin. Non-invasive techniques can be useful in evaluating and quantifying the moisturising and hydrating properties of topically applied urea. Amongst these, transepidermal water loss, skin conductance and capacitance are the most widely used. Dynamic tests and mapping of skin moisturisation are additional features that can be used to evaluate the dynamics of water into the stratum corneum. Ultrasound and mechanical properties can be used to investigate the effects on skin smoothness and tone. In conclusion, urea is a fundamental ingredient of cosmetic and dermatological formulations and can have several positive effects on skin function. These can be easily investigated and monitored using non-invasive techniques measuring the stratum corneum function.
尿素是一种在临床皮肤科中广泛使用的保湿剂，用于滋润和保护皮肤。非侵入性技术可用于评估和量化局部应用尿素的保湿和补水特性。其中，经皮水分流失、皮肤电导率和电容是最常用的方法。动态测试和皮肤保湿映射是可用于评估水进入角质层动态的附加功能。超声和机械特性可用于研究对皮肤光滑度和色调的影响。总之，尿素是化妆品和皮肤科制剂的基本成分，对皮肤功能有多种积极影响。使用测量角质层功能的非侵入性技术可以轻松地进行这些研究和监测。
