来自……的稀有A型、螺环型和高度寡聚原花青素
Rare A-Type, Spiro-Type, and Highly Oligomeric Proanthocyanidins from .
作者信息
Zhou Bin, Alania Yvette, Reis Mariana C, McAlpine James B, Bedran-Russo Ana K, Pauli Guido F, Chen Shao-Nong
机构信息
Department of Pharmaceutical Sciences (PSCI), College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
出版信息
Org Lett. 2020 Jul 17;22(14):5304-5308. doi: 10.1021/acs.orglett.0c01439. Epub 2020 Jul 8.
An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (-) from pine bark. Pinutwindoublin () is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin () represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin () was elucidated as a mixed A + B-type hexamer that consists of a peanut-derived tetramer, peanut procyanidin E, and an A-type dimer (). Compound increased the modulus of elasticity of dentin by an impressive 4.3 times at a concentration of 0.65%.
对牙科生物活性原花青素（PAC）低聚物组分的研究从松树皮中分离出三种结构不同的新型PAC（-）。松风双黄酮（）是首次报道的具有双A型黄酮间键（2α→O→5,4α→6和2α→O→7,4α→8）的三聚体。松螺四环素（）是首次报道的具有由一个螺环型和一个A型二聚体组成的异二聚体框架的PAC四聚体。松麻六黄酮（）被阐明为一种混合A + B型六聚体，由花生衍生的四聚体、花生原花青素E和一个A型二聚体（）组成。化合物在浓度为0.65%时，将牙本质的弹性模量提高了令人印象深刻的4.3倍。
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