Departments of Obstetrics and Gynecology, Ekiti State University, Ado-Ekiti, Nigeria.
Department of Radiology, Ekiti State University, Ado-Ekiti, Nigeria.
Int J Gynaecol Obstet. 2020 Nov;151(2):209-213. doi: 10.1002/ijgo.13302. Epub 2020 Aug 5.
To evaluate use of second-trimester uterine artery Doppler velocimetry to predict adverse pregnancy outcomes.
A prospective longitudinal study among low-risk nulliparous women with singleton pregnancies attending Ekiti State University Teaching Hospital, Nigeria, between July and December 2017. Uterine artery Doppler indices were measured at 22-26 gestational weeks. Resistance index (RI) of 0.58 or less and pulsatility index (PI) of 1.6 or less were considered normal. The ability of Doppler indices to predict adverse pregnancy outcomes was determined.
Among 120 women, 73 (60.8%) women had at least one abnormal Doppler index and 50 (41.7%) at least one adverse pregnancy outcome. For pre-eclampsia, sensitivity and specificity of RI were 40.0% and 37.3% (area under curve [AUC], 0.28), and those of PI were 20.0% and 89.1% (AUC, 0.33) respectively. For intrauterine growth restriction, sensitivity and specificity of RI were 23.1% and 34.6% (AUC, 0.22), and those of PI were 0% and 86.95% (AUC, 0.48), respectively. For low birthweight, sensitivity and specificity of RI were 60.0% and 38.9% (AUC, 0.54), and those of PI were 20.0% and 90.5% (AUC, 0.55), respectively.
Late second-trimester uterine artery Doppler velocimetry had limited ability to predict adverse pregnancy outcomes in a low-risk population.
评估使用中期子宫动脉多普勒血流速度预测不良妊娠结局。
这是一项前瞻性纵向研究，纳入了 2017 年 7 月至 12 月期间在尼日利亚埃基提州立大学教学医院就诊的低危初产妇单胎妊娠。在 22-26 孕周时测量子宫动脉多普勒指数。阻力指数（RI）<0.58 和搏动指数（PI）<1.6 被认为是正常的。确定多普勒指数预测不良妊娠结局的能力。
在 120 名女性中，73 名（60.8%）女性至少有一个异常的多普勒指数，50 名（41.7%）至少有一个不良妊娠结局。对于子痫前期，RI 的敏感性和特异性分别为 40.0%和 37.3%（曲线下面积 [AUC]，0.28），PI 的敏感性和特异性分别为 20.0%和 89.1%（AUC，0.33）。对于宫内生长受限，RI 的敏感性和特异性分别为 23.1%和 34.6%（AUC，0.22），PI 的敏感性和特异性分别为 0%和 86.95%（AUC，0.48）。对于低出生体重，RI 的敏感性和特异性分别为 60.0%和 38.9%（AUC，0.54），PI 的敏感性和特异性分别为 20.0%和 90.5%（AUC，0.55）。
在低危人群中，晚期子宫动脉多普勒血流速度对预测不良妊娠结局的能力有限。
