HLA - B27亚型与HLA - C基因座等位基因的不同连锁不平衡。

Different linkage disequilibria of HLA-B27 subtypes and HLA-C locus alleles.

作者信息

Breur-Vriesendorp B S, de Waal L P, Ivanyi P

机构信息

Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

出版信息

Tissue Antigens. 1988 Aug;32(2):74-7. doi: 10.1111/j.1399-0039.1988.tb01640.x.

DOI:10.1111/j.1399-0039.1988.tb01640.x

PMID:3264088

Abstract

Subtypes of HLA-B27 have been identified by cellular, serological and biochemical techniques. Comparison of the various B27 subtype designations showed the existence of seven B27 subtypes. The new WHO nomenclature (1987) of the B27 subtypes is included. We further report on different linkage disequilibria (ld) of the B27 subtypes. In Caucasoids, the prevalent subtype B27.5 is in ld with Cw1 and Cw2, whereas B27.2 is linked only with Cw2. In Orientals, the most frequent subtypes B27.4 and B27.6 usually occur with Cw3 or Cw blank; B27.5 mostly occurs with Cw2, and B27.2 is almost absent.

摘要

HLA - B27的亚型已通过细胞、血清学和生化技术得以鉴定。对各种B27亚型命名的比较显示存在七种B27亚型。文中包含了世界卫生组织（1987年）关于B27亚型的新命名法。我们进一步报告了B27亚型不同的连锁不平衡情况。在白种人中，流行的B27.5亚型与Cw1和Cw2处于连锁不平衡状态，而B27.2仅与Cw2连锁。在东方人中，最常见的B27.4和B27.6亚型通常与Cw3或空白Cw同时出现；B27.5大多与Cw2同时出现，且几乎不存在B27.2亚型。