应用单稳定同位素示踪法评价北京青春期前儿童红细胞铁的摄取。
Evaluation of Erythrocyte Iron Incorporation in Beijing Prepubertal Children Using a Single Stable Isotope Tracer Method.
机构信息
Key Laboratory of Trace Element Nutrition, MOH, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Department of Preventive Medicine, Changzhi Medical College, Changzhi 046000, Shanxi, China.
出版信息
Biomed Environ Sci. 2020 Jun 20;33(6):414-420. doi: 10.3967/bes2020.056.
OBJECTIVE
To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.
METHODS
Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of Fe twice daily to obtain a total of 30 mg Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14th day, 28th day, 60th day, and 90th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron mass.
RESULTS
The percentage of erythrocyte Fe incorporation increased starting 14 th day, reached a peak at 60 d (boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of Fe obtained for girls in 60th day was significantly higher than those obtained for boys ( < 0.0001).
CONCLUSIONS
The oral administration of Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.
目的
分析红细胞铁掺入率，为青春期前儿童铁营养提供指导。
方法
本研究纳入北京 57 名青春期前儿童，每人每日口服 Fe 3mg，2 次/d，5d 后共摄入 30mgFe。在第 14、28、60 和 90 天测定 RBC 中稳定同位素比值。用稳定同位素比值、血容量和体铁质量计算儿童红细胞铁掺入率。
结果
从第 14 天开始，红细胞铁掺入率逐渐增加，第 60 天达到峰值（男孩：19.67%±0.56%，女孩：21.33%±0.59%），然后逐渐下降。第 60 天女孩的红细胞铁掺入率明显高于男孩（<0.0001）。
结论
儿童口服 Fe 可在 90d 内获得红细胞铁掺入。青春期前女孩应开始增加铁的摄入，进一步的研究应更加关注青春期前儿童的铁状况。
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