Department of Oncology, Jining Cancer Hospital, Jining, Shandong, 272000, P.R. China.
Department of Oncology, Jining No. 1 People's Hospital; Affiliated Jining NO.1 People's Hospital of Jining Medical University, Jining, Shandong, 272011, P.R. China.
Sci Rep. 2020 Jul 8;10(1):11210. doi: 10.1038/s41598-020-66387-x.
Cervical cancer is one of the most common tumors in women. Neutrophils (NEs) and platelets (PLTs) are components of cells in circulating blood. NEs are one of the components of white blood cells (WBCs), accounting for the vast majority of WBCs, recognized as one of the indicators of inflammation. PLTs are associated with thrombosis and inflammation. Both of them play an important role in tumor growth and metastasis. According to pre-radiotherapy PLT and NE media levels, we divided the patients into three groups: PLT and NE both high levels group, single high level group and both low group. By using COX regression models and nomogram, a prognostic model for patients was established. Both high levels of pre-radiotherapy PLT and NE group or high levels of post-radiotherapy PLT and NE group were correlated with worst overall survival (OS) compared with the other two groups. PLT and NE were correlated with outcomes of the patients with locally advanced cervical cancer.
宫颈癌是女性最常见的肿瘤之一。中性粒细胞（NE）和血小板（PLT）是循环血液中细胞的组成部分。NE 是白细胞（WBC）的组成部分之一，占 WBC 的绝大多数，被认为是炎症的指标之一。PLT 与血栓形成和炎症有关。它们在肿瘤生长和转移中都起着重要作用。根据放疗前 PLT 和 NE 介质水平，我们将患者分为三组：PLT 和 NE 均高水平组、单一高水平组和均低水平组。通过 COX 回归模型和列线图，为患者建立了预后模型。与其他两组相比，放疗前 PLT 和 NE 均高水平组或放疗后 PLT 和 NE 高水平组与最差的总生存期（OS）相关。PLT 和 NE 与局部晚期宫颈癌患者的预后相关。
