利用第三代激光球囊进行快速肺静脉隔离——菲尼克斯注册研究
Rapid pulmonary vein isolation utilizing the third-generation laserballoon - The PhoeniX registry.
作者信息
Heeger Christian-H, Tiemeyer Christian M, Phan Huong-Lan, Meyer-Saraei Roza, Fink Thomas, Sciacca Vanessa, Liosis Spyridon, Brüggemann Ben, Große Niels, Fahimi Bezhad, Reincke Samuel, Kuck Karl-Heinz, Ouyang Feifan, Vogler Julia, Eitel Charlotte, Tilz Roland R
机构信息
University Heart Center Lübeck, Division of Electrophysiology, Medical Clinic II (Department of Cardiology, Angiology and Intensive Care Medicine), University Hospital Schleswig-Holstein, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.
出版信息
Int J Cardiol Heart Vasc. 2020 Jul 3;29:100576. doi: 10.1016/j.ijcha.2020.100576. eCollection 2020 Aug.
BACKGROUND
Balloon-based ablation systems for pulmonary vein isolation (PVI) are providing procedural safety and efficacy as well as favourable clinical outcome. Although second-generation laser balloon (LB2) based PVI has been shown safety and efficacy relatively long procedural duration was a strong limitation. The third-generation laser balloon (LB3) offers and automized ablation for rapid PVI. We determined safety, efficacy and procedural characteristics of this new promising ablation system.
METHODS AND RESULTS
A total of 15 consecutive patients were prospectively enrolled. All patients underwent PVI using the LB3. A total 59/59 PVs (100%) were successfully isolated. Procedural data was compared to the last 15 consecutive patients treated by the LB2. The median procedure time significantly declined from LB2 (91 (86, 105) min) to LB3 (77 (68, 87) min), p < 0.001. Similarly, the median left atrial dwelling time significantly decreased from LB2 (72 (62, 84) min) to LB3 (45 (38, 52) min), p < 0.0001. The total laser time decreased from LB2 (1920 (1765, 2193) sec) to LB3 (1077 (896, 1165) sec), p < 0.00001. A pure single shot PVI was performed in 18/59 PVs (31%). For major adverse events no differences were detected between the groups (LB2 1/15 (6.7%) and LB3 1/15 (6.7%), p = 0.999).
CONCLUSION
The LB3 was safe and effective for PVI. Procedure time, LA dwelling time and total laser time significantly decreased compared to LB2.
背景
用于肺静脉隔离（PVI）的基于球囊的消融系统提供了手术安全性、有效性以及良好的临床结果。尽管基于第二代激光球囊（LB2）的PVI已显示出安全性和有效性，但手术时间较长是一个严重的限制。第三代激光球囊（LB3）提供了用于快速PVI的自动化消融。我们确定了这种新的有前景的消融系统的安全性、有效性和手术特征。
方法与结果
前瞻性纳入了连续15例患者。所有患者均使用LB3进行PVI。总共59/59条肺静脉（100%）成功隔离。将手术数据与最后连续15例接受LB2治疗的患者进行比较。手术时间中位数从LB2的91（86，105）分钟显著降至LB3的77（68，87）分钟，p<0.001。同样，左心房停留时间中位数从LB2的72（62，84）分钟显著降至LB3的45（38，52）分钟，p<0.0001。总激光时间从LB2的1920（1765，2193）秒降至LB3的1077（896，1165）秒，p<0.00001。18/59条肺静脉（31%）进行了单纯单次PVI。两组之间未检测到主要不良事件的差异（LB2为1/15（6.7%），LB3为1/15（6.7%），p = 0.999）。
结论
LB3用于PVI是安全有效的。与LB2相比，手术时间、左心房停留时间和总激光时间显著缩短。
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