School of Electromechanical Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Biomed Microdevices. 2020 Jul 8;22(3):47. doi: 10.1007/s10544-020-00502-7.
This study aims to explore the channel patterns and the characteristic parameters of the zigzag microchannel based on microfluidic paper-based analytical devices (μPADs), in which the mixing efficiency and speed can be greatly enhanced. Better mixing of the solutions was obtained by adding a simple directing electric field to the optimized structure of the zigzag microchannel on paper-based chips instead of the traditional complex devices. A higher mixing efficiency was reached when the direct-current (DC) power supply reached 20 V. Meanwhile, a piezoelectric transducer (PZT) driver was used in the mixing experiment with the paper-based zigzag microchannel. The results show that the mixing efficiency reached a maximum value when the input voltage and frequency were 30 V and 150 Hz, respectively. These paper-based devices meet the requirements of the biochemical analysis field because they are low cost, easy to operate, and have high efficiencies, giving them good prospects for future applications. Graphical Abstract.
本研究旨在探索基于微流控纸基分析器件（μPADs）的之字形微通道的通道模式和特征参数，可极大地提高混合效率和速度。通过在纸基芯片上的优化之字形微通道结构上添加简单的定向电场，而不是传统的复杂设备，可更好地混合溶液。当直流（DC）电源达到 20 V 时，可达到更高的混合效率。同时，在纸基之字形微通道的混合实验中使用了压电换能器（PZT）驱动器。结果表明，当输入电压和频率分别为 30 V 和 150 Hz 时，混合效率达到最大值。这些基于纸张的设备因为成本低、易于操作且效率高，符合生化分析领域的要求，因此具有广阔的应用前景。
