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本文引用的文献

1
COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal.新冠病毒疾病在自然状态和免疫抑制状态下：一项临床治疗分期建议。
J Heart Lung Transplant. 2020 May;39(5):405-407. doi: 10.1016/j.healun.2020.03.012. Epub 2020 Mar 20.
2
Ca Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity.钙离子促进中东呼吸综合征冠状病毒与宿主细胞融合并增加感染性。
J Virol. 2020 Jun 16;94(13). doi: 10.1128/JVI.00426-20.
3
Coronavirus membrane fusion mechanism offers a potential target for antiviral development.冠状病毒膜融合机制为抗病毒药物的开发提供了一个潜在的靶点。
Antiviral Res. 2020 Jun;178:104792. doi: 10.1016/j.antiviral.2020.104792. Epub 2020 Apr 6.
4
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
5
The SARS-CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium-Dependent Manner.严重急性呼吸综合征冠状病毒融合肽形成一个扩展的二分融合平台，该平台以钙依赖的方式扰乱膜秩序。
J Mol Biol. 2017 Dec 8;429(24):3875-3892. doi: 10.1016/j.jmb.2017.10.017. Epub 2017 Oct 19.
6
SARS-CoV fusion peptides induce membrane surface ordering and curvature.SARS-CoV 融合肽诱导膜表面有序排列和曲率变化。
Sci Rep. 2016 Nov 28;6:37131. doi: 10.1038/srep37131.
7
Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.细胞信号传导核心的钙：内质网、线粒体和溶酶体之间的相互作用
Trends Biochem Sci. 2016 Dec;41(12):1035-1049. doi: 10.1016/j.tibs.2016.09.001. Epub 2016 Sep 28.
8
Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process.胺碘酮及其代谢产物MDEA通过干扰病毒进入过程来抑制埃博拉病毒感染。
Pathog Dis. 2015 Jul;73(5). doi: 10.1093/femspd/ftv032. Epub 2015 Apr 30.
9
The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry.临床批准的药物胺碘酮、决奈达隆和维拉帕米可抑制丝状病毒进入细胞。
J Antimicrob Chemother. 2014 Aug;69(8):2123-31. doi: 10.1093/jac/dku091. Epub 2014 Apr 7.
10
Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation.人中东呼吸综合征冠状病毒（MERS-CoV）刺突糖蛋白在病毒进入和合胞体形成中的作用。
PLoS One. 2013 Oct 3;8(10):e76469. doi: 10.1371/journal.pone.0076469. eCollection 2013.

Ion channel inhibition against COVID-19: A novel target for clinical investigation.

作者信息

Navarese Eliano P, Musci Rita L, Frediani Lara, Gurbel Paul A, Kubica Jacek

机构信息

Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Department of Cardiology, Azienda Ospedaliera Bonomo, Andria, Italy, Andria, Italy.

出版信息

Cardiol J. 2020;27(4):421-424. doi: 10.5603/CJ.a2020.0090. Epub 2020 Jul 9.

DOI:10.5603/CJ.a2020.0090
PMID:32643141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016015/
Abstract
摘要