移植物抗宿主相关的免疫抑制在混合嵌合体中是由针对宿主或供体淋巴造血细胞的同种异体反应所诱导的。
Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells.
作者信息
Sykes M, Sheard M A, Sachs D H
机构信息
Transplantation Biology Section, National Cancer Institute, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1988 Dec 1;168(6):2391-6. doi: 10.1084/jem.168.6.2391.
Abstract
Graft-vs.-host (GVH)-related immunosuppression has previously been demonstrated in F1 rodent recipients of parental lymphoid cells, and has been thought to result from an immunologic attack of the donor against the host. Since all cells of such F1 recipients could potentially bear target class I MHC alloantigens, it has not previously been possible to determine precisely the target tissues responsible for development of GVH-related effects. In the present studies we have used mixed allogeneic chimeras as recipients of host or donor-strain lymphocyte inocula, and have made the surprising observation that "GVH-induced" immune unresponsiveness does not require GVH reactivity, per se, but develops in the presence of a one-way alloresponse against lymphohematopoietic cells in either the GVH or the host-versus-graft direction.
摘要
移植物抗宿主（GVH）相关的免疫抑制先前已在接受亲本淋巴细胞的F1啮齿动物受体中得到证实，并且一直被认为是由于供体对宿主的免疫攻击所致。由于此类F1受体的所有细胞都可能携带I类主要组织相容性复合体（MHC）同种异体抗原，因此以前无法精确确定导致GVH相关效应的靶组织。在本研究中，我们使用混合同种异体嵌合体作为宿主或供体品系淋巴细胞接种物的受体，并得出了一个惊人的观察结果，即“GVH诱导的”免疫无反应性本身并不需要GVH反应性，而是在对淋巴细胞造血细胞的单向同种异体反应存在的情况下发展，无论是在GVH方向还是宿主抗移植物方向。
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