Al Qahtani Abdulaziz A, Selim Mohie, Hamouda Naglaa H, Al Delamy Abdullah L, Macadangdang Charmaine, Al Shammari Khalaf H, Al Shamary Sahar F
Preventive Medicine Division, Family and Community Medicine Administration, Prince Sultan Military Medical City , Riyadh, Saudi Arabia.
Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University , Assiut, Egypt.
Hum Vaccin Immunother. 2021 Jan 2;17(1):119-123. doi: 10.1080/21645515.2020.1764827. Epub 2020 Jul 9.
: Healthcare Workers (HCWs) constitute a major group exposed to influenza. Researchers herein try to determine the influenza vaccine effectiveness (VE). Influenza VE depends on the vaccinated personal characteristics and the closeness of matching between the vaccine and the prevalent strains of the virus. The aim of our research was to identify the 2018-2019 seasonal influenza VE in HCWs. : a record-based study was carried out using the test-negative design from October 2018 to September 2019 to calculate the influenza VE. HCWs with influenza like illness (ILI) were screened to detect the positive cases, and the vaccination status was determined based on vaccination database. VE was assessed from the ratio of the odds of vaccination among positive cases to the odds of vaccination among negative controls. Statistical analysis Multivariable logistic regression was used to estimate adjusted VE : a total of 556 HCWs presented with ILI, 65.6% were females, and 54.1% were nurses, 152 HCWs (27.3%) had laboratory-confirmed influenza, shows two peaks in January and March 2019. VE for all types was 35.0% and rose to 42.0% after adjustment for HCWs age, gender, nationality, and job position, influenza A (H3N2) VE was 78.0%. H1N1 VE was 55.0% but no significant VE for type B was found. : Our VE estimates are in agreement with VE estimates published for that season. The use of quadrivalent vaccine with two stains of influenza B is recommended.
医护人员是接触流感的主要群体。本文的研究人员试图确定流感疫苗的有效性（VE）。流感疫苗的有效性取决于接种者的个人特征以及疫苗与流行病毒株的匹配程度。我们研究的目的是确定2018 - 2019年医护人员季节性流感疫苗的有效性。：采用检测阴性设计，从2018年10月至2019年9月进行了一项基于记录的研究，以计算流感疫苗的有效性。对患有流感样疾病（ILI）的医护人员进行筛查以检测阳性病例，并根据疫苗接种数据库确定疫苗接种状况。通过阳性病例中接种疫苗的几率与阴性对照中接种疫苗的几率之比来评估疫苗有效性。统计分析采用多变量逻辑回归来估计调整后的疫苗有效性：共有556名医护人员出现流感样疾病，其中65.6%为女性，54.1%为护士，152名医护人员（27.3%）经实验室确诊感染流感，在2019年1月和3月出现两个高峰。所有类型的疫苗有效性为35.0%，在对医护人员的年龄、性别、国籍和工作岗位进行调整后升至42.0%，甲型（H3N2）流感疫苗的有效性为78.0%。H1N1流感疫苗的有效性为55.0%，但未发现乙型流感有显著的疫苗有效性。：我们的疫苗有效性估计与该季节公布的估计结果一致。建议使用含有两种乙型流感毒株的四价疫苗。
