直接观察 FUS/TLS 与启动子相关非编码 RNA 结合时构象的变化。
Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA.
机构信息
Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
National Institutes of Natural Sciences, Exploratory Research Center on Life and Living Systems, Aichi 444-8787, Japan.
出版信息
Chem Commun (Camb). 2020 Aug 11;56(64):9134-9137. doi: 10.1039/d0cc03776a.
PMID:32643734
Abstract
High-speed AFM revealed the conformational change of fused in sarcoma (FUS) from a compact to an extended structure upon binding of non-coding RNA, which is supposed to allow FUS to bind to CBP/p300 for transcriptional interference. Thus, a mechanistic insight into transcription regulation by FUS and non-coding RNA is provided.
摘要
高速原子力显微镜揭示了融合肉瘤（FUS）在结合非编码 RNA 时构象从紧凑变为伸展的变化，这可能使 FUS 能够与 CBP/p300 结合以进行转录干扰。因此，提供了对 FUS 和非编码 RNA 转录调控的机制见解。
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