Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK.
Department of Clinical and Experimental Medicine, Metabolic Diseases Unit, Magna Graecia University, Catanzaro, Italy.
J Med Virol. 2021 Jan;93(1):513-517. doi: 10.1002/jmv.26281. Epub 2020 Jul 21.
In this study, we aimed to highlight the common early-stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID-19) pneumonia.
In hospitalized patients, the acute phase disease duration was followed using the Brescia-COVID respiratory severity scale. Noninvasive ventilation was administered based on clinical judgment. Patients requiring oropharyngeal intubation were excluded from the study. For parameters to be measured at the hospital entrance, age, clinical history, National Early Warning Score 2 (a multiparametric score system), partial pressure of oxygen in arterial blood/fraction of inspired oxygen (P/F ratio), C-reactive protein, and blood cell count were selected.
In 64 patients, age (direct relationship), P/F, and platelet number (inverse relationship) independently accounted for 43% of the acute phase duration of the disease (P < .001).
For the first time, the present results revealed that the acute phase duration of noncomplicated pneumonia, resulting from severe acute respiratory syndrome coronavirus 2, is independently predicted from a patient's age, as well as based on the hospital entrance values of P/F ratio and peripheral blood platelet count.
本研究旨在强调与单纯性 COVID-19 肺炎患者急性期持续时间相关的常见早期临床和实验室变量。
在住院患者中，使用布雷西亚-COVID 呼吸严重程度量表来监测急性期疾病持续时间。根据临床判断给予无创通气。排除需要经口气管插管的患者。对于入院时需要测量的参数，选择年龄、临床病史、国家早期预警评分 2（多参数评分系统）、动脉血氧分压/吸入氧分数（P/F 比值）、C 反应蛋白和血细胞计数。
在 64 例患者中，年龄（直接关系）、P/F 和血小板计数（反比关系）独立解释了疾病急性期持续时间的 43%（P<0.001）。
本研究首次揭示，年龄以及入院时的 P/F 比值和外周血血小板计数可以独立预测由严重急性呼吸综合征冠状病毒 2 引起的非复杂性肺炎的急性期持续时间。
