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珊瑚毒性

Coral Toxicity

作者信息

Dhakal Aayush, Gupta Vikas

机构信息

OBH-Interfaith Medical Center

Wellness Psychiatry P.C

PMID:32644368
Abstract

Corals are invertebrates that fall within the class Anthozoa of the phylum Cnidaria. They are mostly marine inhabitants and typically live in compact colonies of numerous polyps. They are one of the important reef builders in tropical oceans. Many corals, like Zoanthid corals, also known as soft corals, are a very popular component of aquariums (home or public) due to their beauty and low maintenance. Species of Zoanthid corals like  and species can contain a highly toxic and potentially lethal chemical compound known as palytoxin. Coral toxicity, therefore, is palytoxin toxicity. Aquarium shop workers and home aquarium hobbyists may be at increased risk of exposure. So these corals have important implications in human health, but the health risks associated with such corals are often unrecognized or underestimated due to the low volume of cases documented.  Palytoxin (PTX) is a polyhydroxylated and partially desaturated non-proteinaceous substance that is highly toxic. It is one of the largest naturally occurring polymeric products with a molecular weight of 2680 kilodaltons. Its lethal dose in mice, when administered intravenously, is 150 ng/kg body weight. PTX has also been found in certain fishes,  phytoplanktons, and in certain marine bacteria. Toxicity from sources other than corals has also been routinely reported. In recent years the toxicological implications of PTX on human health due to the exposure to soft corals have been on the rise. The number of human poisonings, mostly in aquarium enthusiasts after the manipulation of PTX-contaminated soft corals, is continuously increasing; this is due mainly to the lack of sufficient control over the coral trade, and also underestimation and limited understanding of the entity.

摘要

珊瑚是刺胞动物门珊瑚虫纲的无脊椎动物。它们大多生活在海洋中,通常以众多珊瑚虫紧密聚集形成群体的形式生活。它们是热带海洋中重要的造礁生物之一。许多珊瑚,如纽扣珊瑚(也称为软珊瑚),因其美丽且易于养护,成为家庭或公共水族馆中非常受欢迎的组成部分。像[具体品种1]和[具体品种2]等纽扣珊瑚物种可能含有一种剧毒且有潜在致命性的化合物——岩沙海葵毒素。因此,珊瑚毒性就是岩沙海葵毒素毒性。水族馆店员和家庭水族爱好者接触到这种毒素的风险可能更高。所以这些珊瑚对人类健康有重要影响,但由于记录在案的病例数量较少,与这类珊瑚相关的健康风险往往未被认识或低估。岩沙海葵毒素(PTX)是一种多羟基化且部分不饱和的非蛋白质类剧毒物质。它是天然存在的最大的聚合物产品之一,分子量为2680千道尔顿。给小鼠静脉注射时,其致死剂量为150纳克/千克体重。在某些鱼类、浮游植物和某些海洋细菌中也发现了PTX。来自珊瑚以外来源的毒性也有常规报道。近年来,由于接触软珊瑚,PTX对人类健康的毒理学影响呈上升趋势。人类中毒事件的数量不断增加,主要是在水族爱好者处理受PTX污染的软珊瑚之后;这主要是因为对珊瑚贸易缺乏充分管控,同时对该物质的认识不足且了解有限。