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丙戊酸

Valproic Acid

作者信息

Rahman Masum, Awosika Ayoola O., Nguyen Hoang

机构信息

Boston Medical Center

University of Illinois College of Medicine

Abstract

Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. The mechanism of action for VPA involves the enhancement of inhibitory neurotransmission and the modulation of voltage-gated ion channels. Coordination among interprofessional healthcare professionals, including neurologists, psychiatrists, pharmacists, and nurses, is crucial for appropriate patient selection, dosage adjustment, and monitoring of VPA therapy. This activity analyzes and assesses the indications, pharmacology, potential drug interactions, and adverse effects of VPA therapy, encompassing its effectiveness across various clinical scenarios. Furthermore, this activity also critically reviews the evidence supporting VPA's application in specific populations, including pediatric patients, pregnant women, and older individuals. The assessment also delves into the effectiveness of communication among healthcare providers, patients, and caregivers, regarding the advantages, potential risks, and adherence to VPA treatment.

摘要

丙戊酸(VPA)是一种广泛使用的药物,在各种神经和精神疾病中具有多方面的治疗应用。VPA的治疗用途包括治疗不同类型的癫痫发作、管理双相情感障碍和预防偏头痛。VPA的作用机制包括增强抑制性神经传递和调节电压门控离子通道。跨专业医疗保健专业人员,包括神经科医生、精神科医生、药剂师和护士之间的协作,对于正确选择患者、调整剂量以及监测VPA治疗至关重要。本活动分析和评估VPA治疗的适应症、药理学、潜在药物相互作用和不良反应,包括其在各种临床情况下的有效性。此外,本活动还严格审查支持VPA在特定人群(包括儿科患者、孕妇和老年人)中应用的证据。评估还深入探讨了医疗保健提供者、患者和护理人员之间关于VPA治疗的优势、潜在风险和依从性的沟通效果。

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