眼部结核抗结核治疗后的复发性炎症模式
Pattern of Recurrent Inflammation following Anti-tubercular Therapy for Ocular Tuberculosis.
作者信息
Multani Prabhjot Kaur, Modi Rohit, Basu Soumyava
机构信息
Retina and Uveitis Service, L V Prasad Eye Institute, Bhubaneswar, India.
Hitomi Eye Centre, Mumbai, India.
出版信息
Ocul Immunol Inflamm. 2022 Jan 2;30(1):185-190. doi: 10.1080/09273948.2020.1772838. Epub 2020 Jul 9.
PURPOSE
To investigate recurrence patterns following anti-tubercular therapy (ATT) in different anatomical presentations of ocular tuberculosis (OTB).
METHODS
Retrospective analysis of clinically diagnosed OTB patients divided anatomically into groups A (anterior + intermediate uveitis) and B (posterior + panuveitis). Recurrence was defined as reappearance of intraocular inflammation in a quiescent eye following completion of at least 6-months ATT. Anatomical sites of recurrence were compared to that of presentation.
RESULTS
No significant difference in post-ATT recurrent inflammation was noted between groups A (14.29%, 4/28) and B (8.59%,11/128) ( = .57). Mean follow up was 13.13 ± 14.67 months. All group A recurrences were in the same anatomical segment, whereas in group B, 41.7% (5/11) recurrences were in group A sites. Overall, the group A:B ratio was significantly higher during recurrent inflammation (8:7) than at presentation (28:128) ( < .0001, z-score).
CONCLUSION
Anterior and intermediate uveitis, though uncommon at presentation, are relatively more common during post-ATT recurrences in OTB.
目的
研究抗结核治疗（ATT）后不同解剖表现的眼结核（OTB）的复发模式。
方法
对临床诊断的OTB患者进行回顾性分析，根据解剖部位分为A组（前葡萄膜炎+中间葡萄膜炎）和B组（后葡萄膜炎+全葡萄膜炎）。复发定义为在至少6个月的ATT治疗结束后，静止眼中再次出现眼内炎症。将复发的解剖部位与初次发病的部位进行比较。
结果
A组（14.29%，4/28）和B组（8.59%，11/128）在ATT后复发炎症方面无显著差异（P = 0.57）。平均随访时间为13.13±14.67个月。A组所有复发均发生在相同的解剖节段，而B组中41.7%（5/11）的复发发生在A组的部位。总体而言，复发炎症期间A组与B组的比例（8:7）显著高于初次发病时（28:128）（P < 0.0001，z值）。
结论
前葡萄膜炎和中间葡萄膜炎在初次发病时虽不常见，但在OTB的ATT后复发期间相对更常见。
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