Fling J A, Fischer J R, Boswell R N, Reid M J
Department of Medicine, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236.
J Allergy Clin Immunol. 1988 Dec;82(6):965-70. doi: 10.1016/0091-6749(88)90132-7.
Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.
对107例人类免疫缺陷病毒血清学阳性患者进行了血清免疫球蛋白检测。根据沃尔特·里德分期分类法对每位患者进行分类，并将免疫球蛋白的血清浓度与患者分期进行比较。除9例患者外，所有患者的血清IgM浓度均正常。107例患者中有74例血清IgG浓度升高，疾病严重程度不同阶段之间未发现显著差异。107例患者中有38例血清IgA浓度升高，分期类别增加与血清IgA浓度增加之间存在显著相关性（p = 0.0001）。人类免疫缺陷病毒血清学阳性患者的血清IgA浓度可能是疾病免疫进展的一个有用标志物。
