急性肾损伤中近端肾小管转录因子：最新进展。
Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances.
机构信息
Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York, USA,
Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.
出版信息
Nephron. 2020;144(12):613-615. doi: 10.1159/000508856. Epub 2020 Jul 9.
Abstract
The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. This mini review will highlight the identification and biology of 3 novel TFs in AKI: Sox9, Foxm1, and Foxo3.
摘要
近端小管（PT）是急性肾损伤（AKI）的主要靶点，导致 PT 细胞生物学的深刻变化。在表达早期和强烈变化的基因中，有许多转录因子（TFs），它们本身就是其他转录组变化的原因。在大型测序数据集中正在揭示潜在重要的 TFs；然而，要了解这些 TFs 是否代表适应性或失调性变化，需要进一步的机制研究，这可能揭示新的治疗靶点。本综述将重点介绍 AKI 中 3 种新型 TFs 的鉴定和生物学特性：Sox9、Foxm1 和 Foxo3。
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