Department of Urology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan,
Department of Urology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Urol Int. 2020;104(9-10):789-796. doi: 10.1159/000508765. Epub 2020 Jul 9.
There is increasing interest in evaluating the quality of life of patients with cortisol-producing adrenocortical adenoma (CPA). Our objective was to assess patient-reported health-related quality of life (HRQOL) in patients with CPA compared to non-CPA.
Between January 2012 and September 2015, a total of 24 and 62 patients who had laparoscopic adrenalectomy with CPA and non-CPA, respectively, were included in the study. General HRQOL was evaluated on Short Form 8 (SF-8) questionnaire. The SF-8 questionnaire was administered at preoperative baseline and at 3, 6, 9, 12, 18, and 24 months after adrenalectomy. The impact of changing 2 measures of the summary score on the physical component summary (PCS) and mental component summary (MCS) score of SF-8 was evaluated in prospective and longitudinal studies.
The baseline PCS score was significantly lower in the CPA than in the non-CPA group (43.6 vs. 49.0; p = 0.0075). Thereafter, the PCS score was significantly lower in the CPA group at 3, 6, 9, and 12 months postoperatively. The PCS score increased in the CPA group with no significant difference between both groups at 18 months (48.1 vs. 50.2; p = 0.1202) and 24 months (48.0 vs. 50.8; p = 0.3625) postoperatively. However, the baseline MCS score was not significantly different between the CPA and non-CPA group. The MCS score in both groups gradually increased with no significant differences between the groups at any time points after surgery. The PCS score was not significantly improved at all postoperative points than the baseline score in the CPA and non-CPA group. The MCS score was significantly improved than the baseline score from 6 months postoperatively only in the CPA group.
Our research suggests that laparoscopic adrenalectomy may contribute to improving the physical and mental function in HRQOL.
人们对评估皮质醇分泌性肾上腺腺瘤（CPA）患者的生活质量越来越感兴趣。我们的目的是评估与非 CPA 患者相比，CPA 患者的患者报告的健康相关生活质量（HRQOL）。
在 2012 年 1 月至 2015 年 9 月期间，分别对接受腹腔镜肾上腺切除术治疗的 24 例和 62 例有 CPA 和非 CPA 的患者进行了研究。采用简易健康状况调查问卷（SF-8）评估一般 HRQOL。SF-8 问卷在术前基线以及肾上腺切除术后 3、6、9、12、18 和 24 个月进行评估。前瞻性和纵向研究评估了 SF-8 中两个综合评分变化对生理成分综合评分（PCS）和心理成分综合评分（MCS）的影响。
CPA 组的基线 PCS 评分明显低于非 CPA 组（43.6 对 49.0；p = 0.0075）。此后，CPA 组在术后 3、6、9 和 12 个月时 PCS 评分明显降低。CPA 组的 PCS 评分在术后 18 个月（48.1 对 50.2；p = 0.1202）和 24 个月（48.0 对 50.8；p = 0.3625）时与两组之间无显著差异而增加。然而，CPA 和非 CPA 组之间的基线 MCS 评分没有显著差异。两组的 MCS 评分逐渐升高，术后各时间点两组之间无显著差异。在 CPA 和非 CPA 组中，术后所有时间点的 PCS 评分均未显著高于基线评分。只有在 CPA 组中，从术后 6 个月开始，MCS 评分才显著高于基线评分。
我们的研究表明，腹腔镜肾上腺切除术可能有助于改善 HRQOL 的生理和心理功能。
