TCTP 在生物过程和疾病中的失调。
Dysregulation of TCTP in Biological Processes and Diseases.
机构信息
School of Medicine, Faculty of Science, Medicine & Health, University of Wollongong, Wollongong, NSW 2522, Australia.
Institut Gustave Roussy, Unite Inserm U981, 94805 Villejuif, France.
出版信息
Cells. 2020 Jul 7;9(7):1632. doi: 10.3390/cells9071632.
Abstract
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer.
摘要
翻译控制肿瘤蛋白（TCTP），也称为组氨酸释放因子（HRF）或福瑞汀，是一种存在于几乎所有真核生物中的多功能蛋白。TCTP 参与了一系列基本的细胞生物学过程，如促进生长和发育，或对生物应激的细胞防御。细胞 TCTP 水平受到多种生理信号的高度调节，并且已经阐明了各种水平的调节机制。鉴于 TCTP 在维持细胞内稳态中的重要性，毫不奇怪，这种蛋白质的失调与一系列疾病过程有关。在这里，我们综述了在描述 TCTP 的基本生物学功能、参与调节其细胞水平的机制以及理解 TCTP 失调方面的最新进展，因为它发生在癌症等疾病过程中。
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