Lafuente Marta, Pellejero Ismael, Clemente Alberto, Urbiztondo Miguel A, Mallada Reyes, Reinoso Santiago, Pina María P, Gandía Luis M
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain.
Department of Chemical & Environmental Engineering, University of Zaragoza, Edificio I+D+i, Campus Rio Ebro, C/Mariano Esquillor s/n, 50018 Zaragoza, Spain.
ACS Appl Mater Interfaces. 2020 Aug 12;12(32):36458-36467. doi: 10.1021/acsami.0c06725. Epub 2020 Jul 30.
We present a simple, versatile, and low-cost approach for the preparation of surface-enhanced Raman spectroscopy (SERS)-active regions within a microfluidic channel 50 cm in length. The approach involves the UV-light-driven formation of polyoxometalate-decorated gold nanostructures, Au@POM (POM: HPWO (PW) and HPMoO (PMo)), that self-assemble in situ on the surface of the polydimethylsiloxane (PDMS) microchannels without any extra functionalization procedure. The fabricated LoCs were characterized by scanning electron microscopy (SEM), UV-vis, Raman, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. The SERS activity of the resulting Au@POM-coated lab-on-a-chip (LoC) devices was evaluated in both static and flow conditions using rhodamine R6G. The SERS response of Au@PW-based LoCs was found to be superior to Au@PMo counterparts and outstanding when compared to reported data on metal@POM nanocomposites. We demonstrate the potentialities of both Au@POM-coated LoCs as analytical platforms for real-time detection of the organophosphorous pesticide paraoxon-methyl at 10 M concentration level.
我们提出了一种简单、通用且低成本的方法，用于在长度为50厘米的微流控通道内制备具有表面增强拉曼光谱（SERS）活性的区域。该方法涉及通过紫外光驱动形成多金属氧酸盐修饰的金纳米结构Au@POM（POM：HPWO（PW）和HPMoO（PMo）），这些结构在聚二甲基硅氧烷（PDMS）微通道表面原位自组装，无需任何额外的功能化步骤。通过扫描电子显微镜（SEM）、紫外可见光谱、拉曼光谱、X射线衍射（XRD）和X射线光电子能谱（XPS）技术对制备的芯片实验室（LoC）进行了表征。使用罗丹明R6G在静态和流动条件下评估了所得Au@POM涂层芯片实验室（LoC）器件的SERS活性。发现基于Au@PW的LoC的SERS响应优于基于Au@PMo的LoC，并且与已报道的金属@POM纳米复合材料的数据相比非常出色。我们展示了Au@POM涂层LoC作为分析平台在10 M浓度水平实时检测有机磷农药对氧磷甲基的潜力。
