Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan.
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, 38000, Pakistan.
Mini Rev Med Chem. 2021;21(18):2747-2763. doi: 10.2174/1389557520666200709175948.
Nature has always proved to be a significant reservoir of bioactive scaffolds that have been used for the discovery of drugs since times. Medicinal plants continue to be a solid niche for biologically active and therapeutically effective chemical entities, opening up new avenues for the successful treatment of several human diseases. The contribution of plant-derived compounds to drug discovery, either in their original or in the semi-synthetic derivative form, extends far back in time. This review aims to focus on the sources, biological, and pharmacological profile of a pharmacologically active plant-derived coumarin, osthole, which is an important component of numerous remedial plants such as Cnidium monnieri. Several studies have revealed that osthole possess pharmacological properties such as anticancer, antioxidant, anti-hyperglycemic, neuroprotective, and antiplatelet. Osthole has been reported to regulate various signaling pathways, which in turn modulate several apoptosis-related proteins, cell cycle regulators, protein kinases, transcriptional factors, cytokines, and growth receptors affiliated with inflammation, proliferation and several other ailments. Osthole is known to halt proliferation and metastasis of cancerous cells by arresting the cell cycle and inducing apoptosis. The data in this review paper supports the pharmacological potential of osthole but further experimentation, biosafety profiling and synergistic effects of this compound need to be focused by the researchers to understand the full spectrum of pharmacological potential of this therapeutically potent compound.
自然界一直是生物活性支架的重要来源，这些支架自远古时代以来就被用于药物发现。药用植物仍然是具有生物活性和治疗效果的化学实体的坚实领域，为成功治疗多种人类疾病开辟了新途径。植物来源的化合物对药物发现的贡献，无论是以原始形式还是半合成衍生物形式，都可以追溯到很久以前。本综述旨在重点介绍植物来源香豆素奥氏酮的来源、生物学和药理学特性，奥氏酮是许多药用植物（如蛇床子）的重要成分。多项研究表明，奥氏酮具有抗癌、抗氧化、抗高血糖、神经保护和抗血小板等药理作用。奥氏酮已被报道能够调节多种信号通路，进而调节与炎症、增殖和其他几种疾病相关的几种凋亡相关蛋白、细胞周期调节剂、蛋白激酶、转录因子、细胞因子和生长受体。奥氏酮通过阻止细胞周期和诱导细胞凋亡来阻止癌细胞的增殖和转移。本文中的数据支持奥氏酮的药理学潜力，但需要研究人员进一步进行实验、生物安全性分析和该化合物的协同作用研究，以了解这种治疗有效化合物的全部药理学潜力。
