Han Yingqi, Sun Zhengao
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, 16369 Jingshi Road, Lixia District, Jinan, Shangdong Province, 250014, China.
Department of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 42 Wenhua West Road, Lixia District, Jinan, Shangdong Province, 250014, China.
Pharmacol Rep. 2025 Feb;77(1):87-102. doi: 10.1007/s43440-024-00685-3. Epub 2024 Dec 2.
Gynecological tumors, such as ovarian, endometrial, and cervical cancers, alongside breast cancer, represent significant malignancies that pose serious threats to women's health worldwide. Standard treatments, including surgery, chemotherapy, radiotherapy, and targeted therapies, are commonly utilized in clinical practice. However, challenges such as high recurrence rates, drug resistance, and adverse side effects underscore the urgent need for more effective therapeutic options. Osthole, a natural coumarin compound derived from Chinese herbal medicine, has demonstrated remarkable antitumor activity against various cancers. Emerging evidence indicates that osthole can inhibit the proliferation, invasion, and metastasis of gynecological and breast cancer cells through various mechanisms, including inducing apoptosis and autophagy, regulating the tumor microenvironment, inhibiting tumor angiogenesis, and enhancing the sensitivity of cancer cells to chemotherapy and radiotherapy. This review highlights the recent advancements in osthole research within the context of gynecological and breast cancers, focusing on its molecular mechanisms, and offers a theoretical foundation for its potential development as an anticancer agent.
妇科肿瘤，如卵巢癌、子宫内膜癌和宫颈癌，以及乳腺癌，是全球范围内对女性健康构成严重威胁的重大恶性肿瘤。包括手术、化疗、放疗和靶向治疗在内的标准治疗方法在临床实践中普遍使用。然而，高复发率、耐药性和不良副作用等挑战凸显了对更有效治疗方案的迫切需求。蛇床子素是一种从中药中提取的天然香豆素化合物，已显示出对多种癌症具有显著的抗肿瘤活性。新出现的证据表明，蛇床子素可通过多种机制抑制妇科和乳腺癌细胞的增殖、侵袭和转移，这些机制包括诱导细胞凋亡和自噬、调节肿瘤微环境、抑制肿瘤血管生成以及增强癌细胞对化疗和放疗的敏感性。本综述重点介绍了蛇床子素在妇科和乳腺癌研究方面的最新进展，聚焦于其分子机制，并为其作为抗癌药物的潜在开发提供理论基础。
