de Carvalho Kênia M B, Pizato Nathalia, Botelho Patrícia B, Dutra Eliane S, Gonçalves Vivian S S
Graduate Program in Human Nutrition, Department of Nutrition, University of Brasilia, UnB, Brasília, 70910-900, Brazil.
Department of Nutrition, University of Brasilia, UnB, Brasília, Brazil.
Eur J Nutr. 2020 Sep;59(6):2317-2332. doi: 10.1007/s00394-020-02321-1. Epub 2020 Jul 10.
This systematic review aimed to synthesize the available evidence on the effects of a high-protein diet on appetite sensations in individuals with overweight and obesity.
Two authors independently conducted literature searches, study selection, design of the method, and quality appraisal. The main inclusion criteria were studies involving protocols that present a protein intake greater than 1.2 g/kg/day or 25% of the total daily energy content compared to a normal protein diet, i.e., 0.8-1.2 g/kg/day or 15%-20% of the total energy content. Studies that evaluated test meals or diet within a period of less than 7 days and participants with diabetes, cancer, or other specific conditions were excluded from this review. The literature search was updated until November 2019 using the main databases available.
Of a total of 4191 records, ten articles met the inclusion criteria and included a total of 1079 subjects. In six studies, participants experienced enhanced fullness or satiety in response to a high-dietary protein intake, of which four studies had an intervention period of 10-12 weeks.
Our results suggest that among individuals with overweight or obesity, higher dietary protein intake may influence appetite sensations by enhancing fullness or satiety. The low level of evidence, due to the heterogeneity of the protocols and the high risk of bias, highlights the need for further studies to confirm these results.
本系统评价旨在综合现有证据，探讨高蛋白饮食对超重和肥胖个体食欲的影响。
两位作者独立进行文献检索、研究筛选、方法设计和质量评估。主要纳入标准为：与正常蛋白质饮食（即0.8 - 1.2克/千克/天或总能量的15% - 20%）相比，蛋白质摄入量大于1.2克/千克/天或占每日总能量25%的研究方案。本评价排除了评估少于7天的试验餐或饮食的研究，以及患有糖尿病、癌症或其他特定疾病的参与者。使用主要可用数据库更新文献检索至2019年11月。
在总共4191条记录中，10篇文章符合纳入标准，共纳入1079名受试者。在6项研究中，参与者因高膳食蛋白质摄入量而饱腹感增强，其中4项研究的干预期为10 - 12周。
我们的结果表明，在超重或肥胖个体中，较高的膳食蛋白质摄入量可能通过增强饱腹感来影响食欲。由于方案的异质性和高偏倚风险，证据水平较低，这突出了需要进一步研究来证实这些结果。
