Fehlow P, Tennstedt A
Bezirkskrankenhaus für Psychiatrie und Neurologie Mühlhausen.
Psychiatr Neurol Med Psychol (Leipz). 1988 Jun;40(6):348-52.
Among 2000 dead we found a frequency of death by bolus of about 1% in neuropsychiatric patients in the course of 17 years. Severe oligophrenia mostly combined with epilepsy was leading with almost 50% followed by depressive syndrome, schizophrenia and dementia. Organic cerebral lesion, disorders of activity and vigilance, longterm psychopharmacotherapy, alteration of condition by acute internal disease and perhaps disorders of the liver are considered to be risks of death by bolus.
在2000名死者中，我们发现在17年的时间里，神经精神疾病患者因单次大剂量用药导致死亡的频率约为1%。重度智力发育不全大多与癫痫并发，占主导地位，几乎达到50%，其次是抑郁综合征、精神分裂症和痴呆症。器质性脑损伤、活动和警觉性障碍、长期精神药物治疗、急性内科疾病导致的病情变化以及可能的肝脏疾病被认为是单次大剂量用药致死的风险因素。
