建立点突变对蛋白质稳定性影响的模型。

Modeling the impact of point mutations on the stability of proteins.

机构信息

Department of Medical Physics, Peter the Great, St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.

Department of Molecular Biophysics, St. Petersburg State University, 199034 St. Petersburg, Russia.

出版信息

J Bioinform Comput Biol. 2020 Aug;18(4):2050019. doi: 10.1142/S0219720020500195. Epub 2020 Jul 10.

DOI:10.1142/S0219720020500195

PMID:32649259

Abstract

A new method has been introduced which allows us to determine the stability of protein complexes with point changes of amino acid residues that also take into account the three-dimensional structure of the complex. This formulated and proven theorem is aimed at determining the criterion for the stability of protein molecules. The algorithm and software package were developed for analyzing protein interactions, taking into account their three-dimensional structure from the PDB database.

摘要

现已引入一种新方法，使我们能够确定氨基酸残基点变化的蛋白质复合物的稳定性，同时还考虑到复合物的三维结构。该定理的形式化和证明旨在确定蛋白质分子稳定性的标准。该算法和软件包是为分析蛋白质相互作用而开发的，考虑了来自 PDB 数据库的它们的三维结构。