UMRS 1269 INSERM/Sorbonne University, Nutriomics, Faculté de médecine Pitié-Salpêtrière, F-75013, Paris, France; Member of the scientific council of the Groupe d'Etude et de Recherche en Lipidomique (GERLI), France.
Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France; Member of the scientific council of the Groupe d'Etude et de Recherche en Lipidomique (GERLI), France.
Biochimie. 2020 Dec;179:257-265. doi: 10.1016/j.biochi.2020.07.001. Epub 2020 Jul 8.
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
很明显，除了衰老和各种心脏病理学外，体重过多，尤其是肥胖，是 COVID-19 感染严重程度的主要危险因素。有趣的是，SARS-CoV-2 的受体是 ACE2，它是血管紧张素受体家族的成员，具有相对较大的组织分布。这一观察结果可能解释了从人类患者身上描述的多种症状。脂肪组织也表达 ACE2，这表明脂肪细胞可能被 SARS-CoV-2 感染。在这里，我们讨论了脂肪组织对感染严重程度的一些潜在贡献，并提出了肥胖患者代谢表型的一些方面，以帮助对患有严重疾病高风险的个体进行分层。
