Kelly M E, Bisby M A, Lukowiak K
Department of Medical Physiology, University of Calgary, Alta, Canada.
Can J Physiol Pharmacol. 1988 Jul;66(7):942-5. doi: 10.1139/y88-153.
In bullfrog sympathetic B cells, axotomy decreases the amplitude and decay time of membrane afterhyperpolarization (AHP) and increases action potential (AP) duration. A second (test) axotomy, 7 days after an initial (conditioning) axotomy, did not amplify these changes. No recovery of AHP amplitude or AP duration occurred by 56 days post-axotomy, but AHP decay time recovered 21 days earlier than after test axotomy alone. Conditioning, previously shown to accelerate regeneration, speeds the return to normal of those membrane properties previously shown to recover after axotomy.
在牛蛙交感神经B细胞中，轴突切断术会降低膜超极化后电位（AHP）的幅度和衰减时间，并增加动作电位（AP）的持续时间。在初次（预处理）轴突切断术7天后进行第二次（测试）轴突切断术，并不会放大这些变化。轴突切断术后56天，AHP幅度或AP持续时间均未恢复，但AHP衰减时间比仅进行测试性轴突切断术提前21天恢复。预处理先前已被证明可加速再生，它能加快那些先前已表明在轴突切断术后会恢复的膜特性恢复到正常水平的速度。
