Takano K, Shizume K, Hibi I, Suwa S, Okada Y
Department of Medicine, Tokyo Women's Medical College, Japan.
Endocrinol Jpn. 1988 Aug;35(4):631-8. doi: 10.1507/endocrj1954.35.631.
The body height, weight and growth velocity were investigated in 416 patients with Turner's syndrome whose age ranged from 3 to 17 years. They were all prepubertal at the time of the present study. The chromosomal analysis revealed 45, X monosomy in 148 cases, mosaicism in 208 cases, and nonmosaic structural abnormalities of X chromosome in 60 cases. There were no significant differences in height, growth velocity and weight between the patients with the 45, X karyotype and those with other chromosomal variants at any age. Combined mean heights at 3, 10 and 17 years of age were 86.0 +/- 3.5 (m +/- SD), 116.7 +/- 5.8 and 136.8 +/- 4.8 cm, respectively. These values were below -2.0 SD of normal Japanese girls. The growth velocity was 6.0 +/- 0.5 cm/year at 4 years of age, but decreased gradually and was 1.6 +/- 0.7 cm/year at 17 years of age. The degree of overweight was within +/- 10% of ideal body weight for height between the ages of 3 and 8, 10-20% between the ages of 9 and 10, and 20-30% above the age of 11 years.
对416例年龄在3至17岁的特纳综合征患者的身高、体重和生长速度进行了研究。在本研究时，他们均处于青春期前。染色体分析显示，148例为45,X单体型，208例为嵌合体，60例为X染色体的非嵌合结构异常。在任何年龄，45,X核型患者与其他染色体变异患者在身高、生长速度和体重方面均无显著差异。3岁、10岁和17岁时的联合平均身高分别为86.0±3.5（米±标准差）、116.7±5.8和136.8±4.8厘米。这些数值低于正常日本女孩标准差的-2.0。4岁时生长速度为6.0±0.5厘米/年，但逐渐下降，17岁时为1.6±0.7厘米/年。超重程度在3至8岁时为身高理想体重的±10%以内，9至10岁时为10-20%，11岁以上时为20-30%。
