Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
J Infect Chemother. 2020 Sep;26(9):1008-1010. doi: 10.1016/j.jiac.2020.06.014. Epub 2020 Jul 8.
Some macrolides such as 14- and 15-membered macrolides have immunomodulatory effects such as suppression of mucin overproduction. Because a novel macrolide, solithromycin, was developed, we examined whether it suppresses the overexpression of mucin in vitro. A human airway epithelial cell line NCI-H292 was stimulated by Pseudomonas aeruginosa lipopolysaccharides to induce the overproduction of a major mucin, MUC5AC. Treatment with 10 μg/mL of solithromycin significantly inhibited LPS-induced MUC5AC in both mRNA and protein levels as well as a 15-membered macrolide, azithromycin. These findings support that solithromycin has a potential immunomodulatory effect.
一些大环内酯类药物，如 14 元和 15 元大环内酯类药物，具有免疫调节作用，如抑制粘蛋白过度产生。由于开发了一种新型大环内酯类药物，索利霉素，我们研究了它是否能抑制体外粘蛋白的过度表达。用人呼吸道上皮细胞系 NCI-H292 被铜绿假单胞菌脂多糖刺激，以诱导主要粘蛋白 MUC5AC 的过度产生。10μg/ml 的索利霉素处理显著抑制 LPS 诱导的 MUC5AC 在 mRNA 和蛋白水平上的表达，以及 15 元大环内酯类药物，阿奇霉素。这些发现支持索利霉素具有潜在的免疫调节作用。
