Department of Neuroscience, Neurology, Uppsala University, Sweden.
J Parkinsons Dis. 2020;10(4):1529-1534. doi: 10.3233/JPD-202114.
Levodopa/carbidopa intestinal gel (LCIG) infusion is an efficacious treatment of motor and non-motor fluctuations in people with Parkinson's disease (PD). Real-life use of the treatment is not previously studied.
The aims of the study were to explore the use of LCIG and to determine how extra doses of LCIG are used in daily life.
Twenty-five PD patients with ongoing LCIG therapy were consecutively included. Pump data was retrieved from 30 days on average, by means of software, extracting the most recent pump events.
The daily duration of infusion was 15 hours on average, in 18 patients, whereas the remaining 7 patients used 24-hour infusion. Morning doses ranged from 38-190 mg levodopa, for patients who utilized this function. Median number of daily extra doses was 2.5 (range: 0-10.6) and median size of the extra dose was 24 mg (0-80 mg) levodopa. Median total daily levodopa intake with LCIG was 1201 mg (range: 417-2322 mg).
Retrieving pump data is possible and may be important for evaluating the at-home use of LCIG, to optimize the therapy. Adherence to treatment should be monitored, which is not technically difficult, at least in device-aided treatments for PD.
左旋多巴/卡比多巴肠凝胶（LCIG）输注是治疗帕金森病（PD）患者运动和非运动波动的有效方法。该治疗方法在现实生活中的应用尚未得到研究。
本研究旨在探讨 LCIG 的使用情况，并确定日常生活中 LCIG 的额外剂量如何使用。
连续纳入 25 名正在接受 LCIG 治疗的 PD 患者。通过软件从平均 30 天的时间中检索泵数据，提取最近的泵事件。
18 名患者的平均输注时间为 15 小时，而其余 7 名患者使用 24 小时输注。使用该功能的患者早晨剂量范围为 38-190mg 左旋多巴。每天额外剂量的中位数为 2.5（范围：0-10.6），额外剂量的中位数大小为 24mg（0-80mg）左旋多巴。LCIG 每日总左旋多巴摄入量中位数为 1201mg（范围：417-2322mg）。
检索泵数据是可行的，对于评估 LCIG 的家庭使用情况、优化治疗可能很重要。至少在 PD 的设备辅助治疗中，应监测治疗的依从性，这在技术上并不困难。
