Giulian D, Vaca K, Johnson B
Department of Neurology, Baylor College of Medicine, Houston, TX 77030.
J Neurosci Res. 1988 Oct-Dec;21(2-4):487-500. doi: 10.1002/jnr.490210240.
Secreted peptides of the nervous system help to regulate neuron-glia and glia-glia interactions during development. These regulatory factors, referred to as glia-promoting factors (GPFs), act on specific classes of glia and include oligodendroglia-stimulating peptides, interleukin-1 (IL-1), colony-stimulating factors (CSF), and fibroblast growth factor (FGF). The maturity of secretory and target cells determines, in part, the ability of a factor to influence glial proliferation, activation, or differentiation. During neural development, GPFs help to control such fundamentally important events as cell movement, neurite outgrowth, and myelination.
神经系统分泌的肽有助于在发育过程中调节神经元与神经胶质细胞以及神经胶质细胞之间的相互作用。这些调节因子，被称为神经胶质促进因子（GPFs），作用于特定类型的神经胶质细胞，包括少突胶质细胞刺激肽、白细胞介素-1（IL-1）、集落刺激因子（CSF）和成纤维细胞生长因子（FGF）。分泌细胞和靶细胞的成熟程度部分决定了一种因子影响神经胶质细胞增殖、激活或分化的能力。在神经发育过程中，GPFs有助于控制诸如细胞运动、神经突生长和髓鞘形成等极其重要的事件。
