Department of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, China.
Bosn J Basic Med Sci. 2021 Jun 1;21(3):305-312. doi: 10.17305/bjbms.2020.4738.
Lysosomal protein transmembrane 4 beta (LAPTM4B) is a protein that contains four transmembrane domains. The impact of LAPTM4B on the malignancy of nasopharyngeal carcinoma (NPC) remains unclear. In the present study, we aimed to investigate the role of LAPTM4B in NPC. NPC tissue samples were used to evaluate the expression of LAPTM4B and its relationship with patient prognosis. Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell proliferation, migration, and invasion. We found that LAPTM4B protein was mainly localized in the cytoplasm and intracellular membranes of NPC cells. LAPTM4B protein was upregulated in NPC tissues and cell lines. High LAPTM4B expression was closely related to pathological subtypes and disease stages in NPC patients. NPC patients with high LAPTM4B expression had a worse prognosis. LAPTM4B knockdown inhibited the proliferation, migration, and invasion ability of NPC cells. LAPTM4B plays a cancer-promoting role in the progression of NPC and may be a potential target for NPC therapy.
溶酶体蛋白跨膜 4β（LAPTM4B）是一种含有四个跨膜结构域的蛋白质。LAPTM4B 对鼻咽癌（NPC）恶性程度的影响尚不清楚。本研究旨在探讨 LAPTM4B 在 NPC 中的作用。使用 NPC 组织样本评估 LAPTM4B 的表达及其与患者预后的关系。此外，我们还抑制了 NPC 细胞系中 LAPTM4B 的表达，并研究了 LAPTM4B 对 NPC 细胞增殖、迁移和侵袭的影响。结果发现，LAPTM4B 蛋白主要定位于 NPC 细胞的细胞质和细胞内膜。LAPTM4B 蛋白在 NPC 组织和细胞系中呈高表达。LAPTM4B 高表达与 NPC 患者的病理亚型和疾病分期密切相关。LAPTM4B 高表达的 NPC 患者预后较差。LAPTM4B 敲低抑制 NPC 细胞的增殖、迁移和侵袭能力。LAPTM4B 在 NPC 的进展中发挥致癌作用，可能是 NPC 治疗的潜在靶点。
