白细胞介素-27 在结核性胸膜炎中的诊断准确性：系统评价和荟萃分析。

Diagnostic accuracy of interleukin-27 in tuberculous pleurisy: a systematic review and meta-analysis.

机构信息

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Medical University, X'ian 710038, China.

School of Clinical Medicine, Xi'an Medical University, X'ian 710038, China.

出版信息

QJM. 2021 Nov 5;114(8):568-576. doi: 10.1093/qjmed/hcaa215.

DOI:10.1093/qjmed/hcaa215

PMID:32652017

Abstract

OBJECTIVE

This study aimed to conduct a systematic review of the diagnostic value of interleukin-27 (IL-27) for tuberculous pleurisy (TP).

METHODS

Literature on IL-27 diagnosis of TP was retrieved and screened from six databases (four English databases and two Chinese databases). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and summary receiver operating characteristic curve (SROC) were measured to assess accurately the comprehensive evaluation of IL-27 for TP.

RESULTS

Eleven studies with a total of 1454 patients were identified in the analysis. The combined diagnostic value of IL-27 for TP was as follows: sensitivity of 0.95 (95% confidence interval [CI]: 0.93-0.97), specificity of 0.91 (95% CI: 0.89-0.92), positive likelihood ratio of 13.99 (95% CI: 7.01-27.93), negative likelihood ratio of 0.07 (95% CI: 0.05-0.10), diagnostic odds ratio of 275.20 (95% CI: 112.83-671.23) and area under the SROC of 0.9830.

CONCLUSION

IL-27 has an excellent diagnostic value for TP and could be used as a diagnostic biomarker for TP.

摘要

目的

本研究旨在对白细胞介素-27（IL-27）诊断结核性胸膜炎（TP）的价值进行系统评价。

方法

从六个数据库（四个英文数据库和两个中文数据库）中检索和筛选关于 IL-27 诊断 TP 的文献。测量汇总敏感性、特异性、阳性似然比、阴性似然比、诊断优势比和综合受试者工作特征曲线（SROC），以准确评估 IL-27 对 TP 的综合评价。

结果

分析中确定了 11 项共 1454 例患者的研究。IL-27 对 TP 的联合诊断价值如下：敏感性为 0.95（95%置信区间 [CI]：0.93-0.97），特异性为 0.91（95% CI：0.89-0.92），阳性似然比为 13.99（95% CI：7.01-27.93），阴性似然比为 0.07（95% CI：0.05-0.10），诊断优势比为 275.20（95% CI：112.83-671.23），SROC 下面积为 0.9830。