Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Stockholm, Sweden; Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
J Card Fail. 2020 Dec;26(12):1034-1042. doi: 10.1016/j.cardfail.2020.06.015. Epub 2020 Jul 9.
Noncardiac surgery is increasingly offered to an older, more comorbid population. The aim was to characterize patients with the diagnosis of heart failure (HF) undergoing elective and emergency noncardiac surgery in a broad, contemporary Swedish cohort, and to assess the short- and long-term mortality in patients with HF as compared with patients without HF.
Data from 200,638 and 97,129 patients undergoing elective and emergency surgical procedures at 23 Swedish university, county, and district hospitals during 2007 to 2013 were analyzed through linkage of the surgical Orbit Database to the National Patient and the Cause of Death registries. In total 7212 patients (3.6%) with a diagnosis of HF before surgery underwent elective and 6455 patients (6.6%) underwent emergency surgery. Patients with HF were older had more comorbidities, and higher mortality than patients without HF. Crude and adjusted risk ratios for 30-day mortality after elective surgery were 5.36 (95% confidence interval [CI] 4.67-6.16) and 1.79 (95% CI 1.50-2.14) (adjusted for comorbidities, surgical risk level, age, and sex). Corresponding data for emergency surgery was 3.84 (95% CI 3.58-4.12) and 1.48 (95% CI 1.31-1.62). Mortality in patients with HF after elective surgery at 30 days, 90 days, and 1 year was 3.2%, 6.5%, and 16.2% and after emergency surgery it was 13.7%, 22.4%, and 39.3%.
Patients with HF undergoing elective or emergency noncardiac surgery in a modern surgical setting have a substantial mortality risk and HF is both a risk factor and a strong marker for increasd risk. The reasons for the high mortality are not well-understood and warrant further attention.
非心脏手术越来越多地提供给年龄更大、合并症更多的人群。目的是在广泛的当代瑞典队列中描述接受择期和急诊非心脏手术的心力衰竭(HF)患者,并评估 HF 患者与无 HF 患者相比的短期和长期死亡率。
通过将手术轨道数据库与国家患者和死因登记处进行链接,分析了 2007 年至 2013 年期间在 23 家瑞典大学、县和地区医院接受择期和急诊手术的 200638 名和 97129 名患者的数据。共有 7212 名(3.6%)术前诊断为 HF 的患者接受了择期手术,6455 名(6.6%)患者接受了急诊手术。HF 患者比无 HF 患者年龄更大、合并症更多,死亡率更高。择期手术后 30 天死亡率的粗死亡率比和调整后风险比分别为 5.36(95%置信区间 [CI] 4.67-6.16)和 1.79(95% CI 1.50-2.14)(调整了合并症、手术风险水平、年龄和性别)。急诊手术的相应数据为 3.84(95%CI 3.58-4.12)和 1.48(95%CI 1.31-1.62)。择期手术后 30 天、90 天和 1 年的 HF 患者死亡率分别为 3.2%、6.5%和 16.2%,急诊手术后分别为 13.7%、22.4%和 39.3%。
在现代手术环境下接受择期或急诊非心脏手术的 HF 患者死亡率风险很大,HF 既是危险因素,也是增加风险的有力标志。高死亡率的原因尚不清楚,值得进一步关注。