Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605 006, India.
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605 006, India.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1087-1092. doi: 10.1016/j.dsx.2020.06.026. Epub 2020 Jun 18.
Regenerating islet-derived protein 3-beta (Reg3β) and oncostatin-M (OSM), an inducer of Reg3β, are important for the recruitment of macrophages, tissue repair and survival after myocardial infarction. The study was planned to elucidate the diagnostic utility of serum Reg3β and OSM levels for the acute coronary syndrome (ACS).
Forty-two type 2 diabetes mellitus (T2DM) patients with ACS as cases and forty-two T2DM patients as controls were recruited. Routine biochemical investigations, creatine kinase-total (CK-T), and creatine kinase-MB (CK-MB) levels were estimated. Serum Reg3β and OSM levels were analysed by enzyme-linked immunosorbent assay.
Serum Reg3β and OSM levels were significantly higher in cases as compared to controls. Serum Reg3β and OSM levels were positively correlated with random blood glucose, serum CK-total, CK-MB levels, and negatively correlated with serum high-density lipoprotein cholesterol (HDL-C) levels. Receiver operating characteristics curve analysis showed that serum OSM and Reg3β levels can be used for the diagnosis of ACS in patients with T2DM as compared to CK-MB levels. On regression analysis, serum Reg3β level was positively associated with body mass index and negatively with serum HDL-C levels and serum OSM level was positively associated with waist circumference and random blood glucose and negatively with serum HDL-C levels.
Serum Reg3β and OSM levels may be used as complementary markers besides traditional cardiac markers for the diagnosis of ACS in patients with T2DM. However, further studies are still needed to verify our claim.
胰岛衍生蛋白 3-β（Reg3β）和致瘤素 M（OSM）是巨噬细胞募集、组织修复和心肌梗死后存活的重要诱导因子。本研究旨在阐明血清 Reg3β和 OSM 水平对急性冠脉综合征（ACS）的诊断价值。
纳入 42 例 2 型糖尿病（T2DM）合并 ACS 的患者作为病例组，42 例 T2DM 患者作为对照组。测定常规生化指标、肌酸激酶总（CK-T）和肌酸激酶同工酶（CK-MB）水平。采用酶联免疫吸附法分析血清 Reg3β和 OSM 水平。
与对照组相比，病例组血清 Reg3β和 OSM 水平显著升高。血清 Reg3β和 OSM 水平与随机血糖、血清 CK-T、CK-MB 水平呈正相关，与血清高密度脂蛋白胆固醇（HDL-C）水平呈负相关。受试者工作特征曲线分析显示，与 CK-MB 水平相比，血清 OSM 和 Reg3β水平可用于诊断 T2DM 患者的 ACS。回归分析显示，血清 Reg3β水平与体重指数呈正相关，与血清 HDL-C 水平呈负相关，血清 OSM 水平与腰围和随机血糖呈正相关，与血清 HDL-C 水平呈负相关。
血清 Reg3β和 OSM 水平可作为传统心脏标志物的补充标志物，用于诊断 T2DM 患者的 ACS。然而，仍需要进一步的研究来验证我们的结论。
