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小儿活体肝移植中胆肠重建技术。

Bilioenteric Reconstruction Techniques in Pediatric Living Donor Liver Transplantation.

机构信息

Department of Liver Transplantation Izmir Kent Hospital Izmir Turkey Faculty of Medicine Izmir University of Economics Izmir Turkey Department of Pediatric Gastroenterology Ege University Faculty of Medicine Izmir Turkey.

出版信息

Liver Transpl. 2021 Feb;27(2):257-263. doi: 10.1002/lt.25845. Epub 2020 Oct 1.

DOI:10.1002/lt.25845
PMID:32652804
Abstract

Biliary complications (BCs) are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. Although Roux-en-Y (RY) hepaticojejunostomy has been the standard technique for years in pediatric patients, there is a limited number of reports on the feasibility of duct-to-duct (DD) anastomosis, and those reports have controversial outcomes. With the largest number of patients ever reported on the topic, this study aims to discuss the feasibility of the DD biliary reconstruction technique in pediatric living donor liver transplantation (LDLT). After the exclusion of the patients with biliary atresia, patients who received either deceased donor or right lobe grafts, and retransplantation patients, data from 154 pediatric LDLTs were retrospectively analyzed. Patients were grouped according to the applied biliary reconstruction technique, and the groups were compared using BCs as the outcome. The overall BC rate was 13% (n = 20), and the groups showed no significant difference (P = 0.6). Stricture was more frequent in the DD reconstruction group; however, this was not statistically significant (P = 0.6). The rate of bile leak was also similar in both groups (P = 0.6). The results show that the DD reconstruction technique can achieve similar outcomes when compared with RY anastomosis. Because DD reconstruction is a more physiological way of establishing bilioenteric integrity, it can safely be applied.

摘要

胆道并发症 (BCs) 仍然是肝移植后发病率的主要原因,尽管手术技术有所进步。尽管 Roux-en-Y (RY) 胆肠吻合术多年来一直是儿科患者的标准技术,但关于胆管对胆管 (DD) 吻合术可行性的报告数量有限,并且这些报告的结果存在争议。本研究报告了最大数量的患者,旨在讨论 DD 胆道重建技术在小儿活体供肝移植 (LDLT) 中的可行性。排除胆道闭锁患者、接受供体或右叶移植患者以及再次移植患者后,回顾性分析了 154 例小儿 LDLT 的数据。根据应用的胆道重建技术对患者进行分组,并将各组的胆道并发症作为结果进行比较。总体 BC 发生率为 13% (n = 20),两组之间无显著差异 (P = 0.6)。DD 重建组的狭窄更为常见;然而,这没有统计学意义 (P = 0.6)。两组的胆漏发生率也相似 (P = 0.6)。结果表明,DD 重建技术与 RY 吻合术相比可以达到相似的结果。因为 DD 重建是建立胆肠完整性的更生理的方法,所以可以安全应用。

相似文献

1
Bilioenteric Reconstruction Techniques in Pediatric Living Donor Liver Transplantation.小儿活体肝移植中胆肠重建技术。
Liver Transpl. 2021 Feb;27(2):257-263. doi: 10.1002/lt.25845. Epub 2020 Oct 1.
2
Duct-to-duct biliary reconstruction in living donor liver transplantation utilizing right lobe graft.利用右叶供肝行活体肝移植中的胆管对胆管胆肠重建术。
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Relationship Between Bile Duct Reconstruction and Complications in Living Donor Liver Transplantation.活体肝移植中胆管重建与并发症的关系
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Longterm Analysis of Biliary Complications After Duct-to-Duct Biliary Reconstruction in Living Donor Liver Transplantations.活体肝移植中胆管对胆管重建后胆系并发症的长期分析。
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Use of recipient's left hepatic artery for artery reconstruction in right lobe living donor liver transplantation with duct-to-duct anastomosis.受体左肝动脉用于右半肝活体肝移植胆管对胆管吻合的动脉重建。
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A single-center experience with biliary reconstruction in retransplantation: duct-to-duct or Roux-en-Y choledochojejunostomy.单中心再移植中胆肠重建的经验:胆管对胆管或 Roux-en-Y 胆肠吻合术。
Liver Transpl. 2011 Jun;17(6):710-6. doi: 10.1002/lt.22263.

引用本文的文献

1
Duct-to-Duct Anastomosis Versus Bilioenteric Anastomosis for Pediatrics Living Donor Liver Transplantation: A Systematic Review and Meta-Analysis.小儿活体供肝移植中胆管对胆管吻合术与胆肠吻合术的比较:一项系统评价和荟萃分析
Cureus. 2023 Nov 1;15(11):e48108. doi: 10.7759/cureus.48108. eCollection 2023 Nov.
2
The advantages of duct-to-duct biliary reconstruction in pediatric living donor liver transplantation.小儿活体肝移植中胆管对胆管重建的优势。
Pediatr Surg Int. 2023 Nov 2;39(1):286. doi: 10.1007/s00383-023-05568-x.
3
Pediatric living donor liver transplantation (LDLT): Short- and long-term outcomes during sixteen years period at a single centre- A retrospective cohort study.
小儿活体肝移植(LDLT):单中心16年期间的短期和长期结果——一项回顾性队列研究
Ann Med Surg (Lond). 2022 Jun 7;79:103938. doi: 10.1016/j.amsu.2022.103938. eCollection 2022 Jul.
4
North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry.北美儿童肝移植后胆管狭窄管理策略:来自小儿肝移植协会(SPLIT)注册中心的多中心分析。
Liver Transpl. 2022 May;28(5):819-833. doi: 10.1002/lt.26379. Epub 2022 Jan 30.