Department of Liver Transplantation Izmir Kent Hospital Izmir Turkey Faculty of Medicine Izmir University of Economics Izmir Turkey Department of Pediatric Gastroenterology Ege University Faculty of Medicine Izmir Turkey.
Liver Transpl. 2021 Feb;27(2):257-263. doi: 10.1002/lt.25845. Epub 2020 Oct 1.
Biliary complications (BCs) are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. Although Roux-en-Y (RY) hepaticojejunostomy has been the standard technique for years in pediatric patients, there is a limited number of reports on the feasibility of duct-to-duct (DD) anastomosis, and those reports have controversial outcomes. With the largest number of patients ever reported on the topic, this study aims to discuss the feasibility of the DD biliary reconstruction technique in pediatric living donor liver transplantation (LDLT). After the exclusion of the patients with biliary atresia, patients who received either deceased donor or right lobe grafts, and retransplantation patients, data from 154 pediatric LDLTs were retrospectively analyzed. Patients were grouped according to the applied biliary reconstruction technique, and the groups were compared using BCs as the outcome. The overall BC rate was 13% (n = 20), and the groups showed no significant difference (P = 0.6). Stricture was more frequent in the DD reconstruction group; however, this was not statistically significant (P = 0.6). The rate of bile leak was also similar in both groups (P = 0.6). The results show that the DD reconstruction technique can achieve similar outcomes when compared with RY anastomosis. Because DD reconstruction is a more physiological way of establishing bilioenteric integrity, it can safely be applied.
胆道并发症 (BCs) 仍然是肝移植后发病率的主要原因,尽管手术技术有所进步。尽管 Roux-en-Y (RY) 胆肠吻合术多年来一直是儿科患者的标准技术,但关于胆管对胆管 (DD) 吻合术可行性的报告数量有限,并且这些报告的结果存在争议。本研究报告了最大数量的患者,旨在讨论 DD 胆道重建技术在小儿活体供肝移植 (LDLT) 中的可行性。排除胆道闭锁患者、接受供体或右叶移植患者以及再次移植患者后,回顾性分析了 154 例小儿 LDLT 的数据。根据应用的胆道重建技术对患者进行分组,并将各组的胆道并发症作为结果进行比较。总体 BC 发生率为 13% (n = 20),两组之间无显著差异 (P = 0.6)。DD 重建组的狭窄更为常见;然而,这没有统计学意义 (P = 0.6)。两组的胆漏发生率也相似 (P = 0.6)。结果表明,DD 重建技术与 RY 吻合术相比可以达到相似的结果。因为 DD 重建是建立胆肠完整性的更生理的方法,所以可以安全应用。