Dodé C, Labie D, Rochette J
INSERM U 15, CHU Cochin, Paris.
Ann Genet. 1988;31(4):201-4.
We have determined alpha+ deletional thalassemia among 143 Southeast Asia refugees (Cambodians, Laotians, and Vietnameses). Gene frequency of alpha+ deletional thalassemia in Vietnameses (0.035) was found lower than in Cambodians and Laotians (0.11). Bam H1 and Bg1 II analysis indicated that both rightward and leftward thalassemias are encountered, the -alpha 3,7 form is being by far more frequent than the -alpha 4.2 one. Only type I cross-over was found by Apa I digestion on -alpha 3.7 chromosomes. The Rsa I polymorphism, 5' to Z alpha 2 block, is associated with -alpha 3.7 type I haplotype and the site is present in 12 out of 23 chromosomes. All these data suggest at least three origins of alpha+-thalassemia in Cambodia and Laos.
我们已在143名东南亚难民（柬埔寨人、老挝人和越南人）中确定了α+缺失型地中海贫血。发现越南人中α+缺失型地中海贫血的基因频率（0.035）低于柬埔寨人和老挝人（0.11）。Bam H1和Bg1 II分析表明，同时存在向右和向左的地中海贫血，其中-α 3,7型远比-α 4.2型更为常见。通过对-α 3.7染色体进行Apa I消化，仅发现了I型交叉。Z α 2基因座5'端的Rsa I多态性与-α 3.7 I型单倍型相关，在23条染色体中有12条存在该位点。所有这些数据表明，柬埔寨和老挝的α+地中海贫血至少有三个起源。
