奥瑞珠单抗治疗复发缓解型多发性硬化症后发生急性胰腺炎。
Acute pancreatitis after ocrelizumab treatment for relapsing remitting multiple sclerosis.
作者信息
Adamec Ivan, Reiner Željko, Pećin Ivan, Šućur Nediljko, Godan Hauptman Ana, Barun Barbara, Gabelić Tereza, Habek Mario
机构信息
University Hospital Center Zagreb Department of Neurology, Referral Center for Autonomic Nervous System Disorders, Zagreb, Croatia.
University Hospital Center Zagreb Department of Internal Medicine, Division of Metabolic Diseases, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.
出版信息
Mult Scler Relat Disord. 2020 Oct;45:102381. doi: 10.1016/j.msard.2020.102381. Epub 2020 Jul 7.
Ocrelizumab is an anti-CD20 monoclonal antibody used in the treatment of relapsing remitting and primary progressive multiple sclerosis. The main side effects are infusion-related with long term administration raising the risk of infections. During randomized controlled trials five cases of pancreatitis have been reported. We present a case of a patient with no risk factors for pancreatitis who after administration developed acute pancreatitis albeit with a good recovery.
奥瑞珠单抗是一种用于治疗复发缓解型和原发性进展型多发性硬化症的抗CD20单克隆抗体。主要副作用与输液有关，长期使用会增加感染风险。在随机对照试验期间，报告了5例胰腺炎病例。我们报告一例无胰腺炎危险因素的患者，在使用奥瑞珠单抗后发生了急性胰腺炎，不过恢复良好。
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