Asok Kumar R, Chinoy N J
Department of Zoology, School of Sciences Gujarat University, Ahmedabad, India.
Endocrinol Exp. 1988 Sep;22(3):187-95.
The effects of acetylsalicylic acid (ASA) at a dose of 800 micrograms/day per rat for 7 days on some androgenic parameters such as organ weights, succinate dehydrogenase, acid phosphatase, fructose, cholesterol and protein of testis, epididymis, vas deferens and accesory glands in adolescent male rats were investigated. The semen characteristics and scanning electron microscopy (SEM) study on sperm morphology of cauda epididymis were also carried out. The results revealed that the treatment manifested a marked effect in altering the metabolism of testis, cauda epididymis, seminal vesicle and vas deferens. The androgen antagonistic and antianabolic effects were by and large transient and reversible by ascorbic acid administration.
研究了以每天每只大鼠800微克的剂量给予乙酰水杨酸（ASA）7天，对青春期雄性大鼠睾丸、附睾、输精管和附属腺体的一些雄激素参数（如器官重量、琥珀酸脱氢酶、酸性磷酸酶、果糖、胆固醇和蛋白质）的影响。还进行了精液特征以及附睾尾部精子形态的扫描电子显微镜（SEM）研究。结果显示，该处理在改变睾丸、附睾尾部、精囊和输精管的代谢方面表现出显著作用。雄激素拮抗和抗合成代谢作用大体上是短暂的，通过给予抗坏血酸可逆转。
