Chinoy N J, Mehta R R, Seethalakshmi L, Sharma J D, Chinoy M R
Int J Fertil. 1986 Jul-Aug;31(3):232-9.
Vitamin C dietary deficiency in guinea pigs markedly affected the androgen-sensitive parameters of the reproductive tissues--testis, epididymis, vas deferens, and accessory sex glands--and caused an "androgen-deprived effect" in these target organs. This in turn altered their internal milieu and caused changes in their metal ion profile and the morphology, motility, and density of spermatozoa in the cauda epididymis and vas deferens. The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs, thus decreasing their fertility rate. The primary action seems to be at the level of the testis, and androgen deprivation and partial antifertility effects are probably secondary manifestations consequent to the primary effect. The present study demonstrated that ascorbic acid is essential for maintaining the physiological integrity of the androgen target reproductive organs in guinea pigs.
豚鼠饮食中缺乏维生素C会显著影响生殖组织（睾丸、附睾、输精管和附属性腺）中对雄激素敏感的参数，并在这些靶器官中产生“雄激素剥夺效应”。这反过来又改变了它们的内部环境，导致其金属离子谱以及附睾尾部和输精管中精子的形态、活力和密度发生变化。坏血病豚鼠的输精管对肾上腺素的敏感性也降低，从而降低了它们的生育率。主要作用似乎发生在睾丸水平，雄激素剥夺和部分抗生育作用可能是主要作用的继发表现。本研究表明，抗坏血酸对于维持豚鼠雄激素靶生殖器官的生理完整性至关重要。
