Dougherty G J, Dransfield I, Hogg N
Macrophage Laboratory, Imperial Cancer Research Fund, London, GB.
Eur J Immunol. 1988 Dec;18(12):2067-71. doi: 10.1002/eji.1830181229.
A monocyte molecule, identified by a monoclonal antibody (mAb) named 24, is involved in the antigen-specific proliferation of T cells. Several types of antigen-induced responses are blocked by mAb24, but mitogen responses, even at low doses, are not. The 24 molecule is found on circulating monocytes and no other cell type. Normally only a proportion of monocytes express the 24 molecule but it can be induced rapidly on monocytes in culture, possibly from intracellular sources. The epitope is present on a heterodimer of 175 and 95 kDa which is similar to the leukocyte cell adhesion molecule (Leu-CAM) family. These findings suggest that although the 24 molecule shows some functional and biochemical similarities with the Leu-CAM family of molecules, it represents a novel structure primarily associated with mononuclear phagocytes.
一种由名为24的单克隆抗体（mAb）识别的单核细胞分子，参与T细胞的抗原特异性增殖。几种类型的抗原诱导反应被mAb24阻断，但丝裂原反应，即使是低剂量的，也不会被阻断。24分子存在于循环单核细胞上，不存在于其他细胞类型上。正常情况下，只有一部分单核细胞表达24分子，但在培养的单核细胞中它可以迅速被诱导，可能来自细胞内来源。该表位存在于175和95 kDa的异二聚体上，与白细胞细胞粘附分子（Leu-CAM）家族相似。这些发现表明，尽管24分子与Leu-CAM分子家族在功能和生化方面有一些相似之处，但它代表了一种主要与单核吞噬细胞相关的新结构。
