Fudo T, Kambara H, Hashimoto T, Hayashi M, Kawai C, Senda M, Tamaki N, Yonekura Y
Third Division of Internal Medicine, Kyoto University.
J Cardiol. 1988 Mar;18(1):13-20.
Myocardial positron emission tomography (PET) using N-13-ammonia (NH3) and F-18-fluorodeoxyglucose (FDG) was performed in 16 patients with myocardial infarction to assess myocardial blood flow and glucose utilization. These PET data were also compared by left ventriculography. N-13-ammonia PET study was performed at rest and after supine ergometer exercise as a measure of myocardial blood flow, and the F-18-FDG PET study was performed at rest after more than five hours' fasting as a measure of glucose utilization. The N-13-ammonia PET study revealed hypoperfused regions in 15 of 16 patients (94%) corresponding to the infarct regions identified by electrocardiography and by cardiac catheterization. In 12 of 16 patients (75%) these hypoperfused regions expanded with exercise. FDG uptake was observed in the hypoperfused regions, especially in stress-induced ischemic ones. Increased uptake of FDG was more often observed in patients with mildly hypokinetic wall motion on left ventriculography. However, FDG PET studies demonstrated diffuse uptake of FDG in some of the akinetic and dyskinetic segments.
对16例心肌梗死患者进行了使用N-13-氨（NH3）和F-18-氟脱氧葡萄糖（FDG）的心肌正电子发射断层扫描（PET），以评估心肌血流和葡萄糖利用情况。这些PET数据还通过左心室造影进行了比较。N-13-氨PET研究在静息状态下和仰卧位测力计运动后进行，以测量心肌血流，F-18-FDG PET研究在禁食超过5小时后的静息状态下进行，以测量葡萄糖利用情况。N-13-氨PET研究显示，16例患者中有15例（94%）存在灌注不足区域，与心电图和心脏导管检查确定的梗死区域相对应。16例患者中有12例（75%）这些灌注不足区域在运动时扩大。在灌注不足区域观察到FDG摄取，尤其是在应激诱导的缺血区域。在左心室造影显示壁运动轻度减弱的患者中，更常观察到FDG摄取增加。然而，FDG PET研究显示，在一些运动不能和运动障碍节段中存在FDG的弥漫性摄取。
