Department of Nephrology-Dialysis, Military Hospital Mohammed V, Rabat, Morocco.
Department of Nephrology-Dialysis, Military Hospital Mohammed V, Agadir, Morocco.
Saudi J Kidney Dis Transpl. 2020 May-Jun;31(3):589-596. doi: 10.4103/1319-2442.289445.
Granulomatous interstitial nephritis (GIN) is a rare cause of renal failure. Most frequent etiologies are sarcoidosis, drugs, granulomatosis with polyangiitis, and infections agents (particularly renal tuberculosis). The aim of this retrospective study was to evaluate the clinical features, causes, and outcomes of patients with GIN in adult patients in a region of Morocco. All native renal biopsy (January 2008 to December 2017) were reviewed, but only cases of GIN were analyzed. Eleven cases of GIN were identified in this study, constituting 2.7 % of all native renal biopsies performed on this period (n = 407). There were 7 (63.6%) women, and the average age was 44.2 ± 13.9 years. The mean serum creatinine level at the renal biopsy was 39.1 ± 20.7 mg/L. The most common etiology was sarcoidosis (45.4%, n = 5) followed by drug-induced GIN (27.2%, n = 3). A good renal outcome was reported in patients with drug-induced GIN and sarcoidosis. However, no renal recovery was described in patients with other etiologies. One information from our report and the previously studies is that better data collection systems such as biopsy registries are needed to provide data on the epidemiology and treatment of rare kidney diseases.
肉芽肿性间质性肾炎（GIN）是导致肾衰竭的罕见原因。最常见的病因是结节病、药物、肉芽肿性多血管炎和感染因子（尤其是肾结核）。本回顾性研究的目的是评估摩洛哥某一地区成人患者 GIN 的临床特征、病因和预后。回顾了 2008 年 1 月至 2017 年 12 月期间所有的原发性肾脏活检，但仅对 GIN 病例进行了分析。本研究共发现 11 例 GIN，占同期（n=407）所有原发性肾脏活检的 2.7%。7 例为女性（63.6%），平均年龄为 44.2±13.9 岁。肾活检时血清肌酐水平平均为 39.1±20.7mg/L。最常见的病因是结节病（45.4%，n=5），其次是药物诱导的 GIN（27.2%，n=3）。药物诱导的 GIN 和结节病患者的肾脏预后良好。然而，其他病因患者则无肾脏恢复的描述。从我们的报告和以前的研究中可以得到的一个信息是，需要更好的数据收集系统，如活检登记处，以提供有关罕见肾脏疾病的流行病学和治疗的数据。
