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血浆作为移植物保存液的组织学和临床评估及其在毛发生长和移植物存活方面的功效。

A Histological and Clinical Evaluation of Plasma as a Graft-holding Solution and Its Efficacy in Terms of Hair Growth and Graft Survival.

作者信息

Garg Anil K, Garg Seema

机构信息

Rejuvenate Hair Transplant, Indore, Madhya Pradesh, India.

Diplomate of American Board of hair Restoration, Rejuvenate hair transplant centre, Indore, India.

出版信息

J Cutan Aesthet Surg. 2020 Jan-Mar;13(1):50-56. doi: 10.4103/JCAS.JCAS_97_19.

DOI:10.4103/JCAS.JCAS_97_19
PMID:32655253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7335469/
Abstract

BACKGROUND

There is a time lag between hair follicle harvesting and implantation; during this time, hair follicles have ischemic injury. We need a holding media or a solution to minimize or neutralize ischemic injury.

AIM AND OBJECTIVES

The aim of this study was to evaluate plasma as a graft-holding solution in terms of its efficacy in hair growth and hair graft survival.

MATERIALS AND METHODS

A split-scalp study was carried out. The left side was designated as the control area (Group A), where graft implanted was kept in Ringer's lactate (RL), and the right side behaved as the test area (Group B), which received grafts preserved in autologous plasma. The value was calculated.

OBSERVATIONS

MTT [3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide] staining for graft stored in RL at 12-72h showed poor hair follicles cells survival, whereas graft kept in plasma showed viable cells even after 72h. The hair count and density in plasma group were significantly higher than the RL group. There was an improvement in hair thickness in both groups from 6 to 12 months.

CONCLUSION

Autologous plasma is an easily available graft-holding solution. Platelets along with the plasma provide multiple growth factors promoting epithelialization, neovascularization, and action on hair follicle stem cells to improve growth. The fibrin coating around graft makes it sticky and prevents dehydration. The split-scalp controlled study certainly shows the advantages of using plasma over other extracellular graft-holding solutions.

摘要

背景

毛囊采集与移植之间存在时间间隔；在此期间，毛囊会发生缺血性损伤。我们需要一种保存介质或溶液来尽量减少或中和缺血性损伤。

目的

本研究旨在评估血浆作为一种移植物保存溶液对毛发生长和毛囊移植物存活的效果。

材料与方法

进行了一项头皮分区研究。左侧指定为对照区域（A组），植入的移植物保存在乳酸林格液（RL）中，右侧作为测试区域（B组），接受保存在自体血浆中的移植物。计算相关数值。

观察结果

对保存在RL中的移植物在12 - 72小时进行MTT [3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐]染色显示毛囊细胞存活情况较差，而保存在血浆中的移植物即使在72小时后仍显示有存活细胞。血浆组的毛发数量和密度显著高于RL组。两组在6至12个月时毛发厚度均有所改善。

结论

自体血浆是一种易于获取的移植物保存溶液。血小板与血浆一起提供多种生长因子，促进上皮化、新血管形成，并作用于毛囊干细胞以促进生长。移植物周围的纤维蛋白涂层使其具有黏性并防止脱水。头皮分区对照研究确实显示了使用血浆优于其他细胞外移植物保存溶液的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/bc88518e3308/JCAS-13-50-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/b3c0cd1ee97d/JCAS-13-50-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/b4d707a44b6c/JCAS-13-50-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/cb05c342e82e/JCAS-13-50-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/9f5ac04da231/JCAS-13-50-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/dab610374443/JCAS-13-50-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/711d68f31661/JCAS-13-50-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/1e74f5a636ac/JCAS-13-50-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/00f360d56463/JCAS-13-50-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/bc88518e3308/JCAS-13-50-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/b3c0cd1ee97d/JCAS-13-50-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/b4d707a44b6c/JCAS-13-50-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/cb05c342e82e/JCAS-13-50-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/9f5ac04da231/JCAS-13-50-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/dab610374443/JCAS-13-50-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/711d68f31661/JCAS-13-50-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/1e74f5a636ac/JCAS-13-50-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/00f360d56463/JCAS-13-50-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5071/7335469/bc88518e3308/JCAS-13-50-g009.jpg

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