Sampedro Agurne, Peña Javier, Ibarretxe-Bilbao Naroa, Cabrera-Zubizarreta Alberto, Sánchez Pedro, Gómez-Gastiasoro Ainara, Iriarte-Yoller Nagore, Pavón Cristóbal, Ojeda Natalia
Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain.
OSATEK, MR Unit, Hospital of Galdakao, Galdakao, Spain.
Front Neurosci. 2020 Jun 23;14:572. doi: 10.3389/fnins.2020.00572. eCollection 2020.
The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, little is known about the brain correlates underlying this impairment. Therefore, the aim of this study was to analyze whole brain white matter (WM) correlates of several creativity dimensions in people with schizophrenia. Fifty-five patients with schizophrenia underwent diffusion-weighted imaging on a 3T magnetic resonance imaging machine as well as a clinical and a creativity assessment, including verbal and figural creativity measures. Tract-based spatial statistic, implemented in FMRIB Software Library (FSL), was used to assess whole brain WM correlates with different creativity dimensions, controlling for sex, age, premorbid IQ, and medication. Mean fractional anisotropy (FA) in frontal, temporal, subcortical, brain stem, and interhemispheric regions correlated positively with figural originality. The most significant clusters included the right corticospinal tract (cerebral peduncle part) and the right body of the corpus callosum. Verbal creativity did not show any significant correlation. As a whole, these findings suggest that widespread WM integrity is involved in creative performance of patients with schizophrenia. Many of these areas have also been related to creativity in healthy people. In addition, some of these regions have shown to be particularly impaired in schizophrenia, suggesting that these WM alterations could be underlying the worse creative performance found in this pathology.
几十年来，创造力与精神病理学之间的关系一直是一个有争议的研究课题。具体而言，已有研究表明，精神分裂症患者在创造性表现方面存在缺陷。然而，对于这种缺陷背后的大脑关联因素却知之甚少。因此，本研究的目的是分析精神分裂症患者几种创造力维度的全脑白质（WM）关联因素。55名精神分裂症患者在3T磁共振成像仪上接受了扩散加权成像以及临床和创造力评估，包括言语和图形创造力测量。在FMRIB软件库（FSL）中实施的基于体素的空间统计学方法，用于评估全脑WM与不同创造力维度的关联，同时控制性别、年龄、病前智商和药物治疗因素。额叶、颞叶、皮质下、脑干和半球间区域的平均各向异性分数（FA）与图形原创性呈正相关。最显著的聚类包括右侧皮质脊髓束（大脑脚部分）和右侧胼胝体。言语创造力未显示出任何显著相关性。总体而言，这些发现表明广泛的WM完整性参与了精神分裂症患者的创造性表现。其中许多区域也与健康人的创造力有关。此外，其中一些区域在精神分裂症中显示出特别受损，这表明这些WM改变可能是这种疾病中较差的创造性表现的潜在原因。
