Chernyshkova Irina, Estefan Bebsy, Hoque Md Rezaul, Lee Alice
Psychiatry, St. Barnabas Health System, Bronx, USA.
Psychiatry, St. Barnabas Medical Center, Bronx, USA.
Cureus. 2020 Jun 7;12(6):e8485. doi: 10.7759/cureus.8485.
We describe a case of probable autoimmune encephalitis developed as a result of paraneoplastic syndrome in a woman with an ovarian teratoma. Patients may present with psychiatric and neurological symptoms, which are caused by anti-N-methyl-D-aspartate (anti-NMDA) receptor antibodies produced in response to a teratoma that crosses the blood-brain barrier and damages brain tissue in the limbic area, causing encephalitis. Our patient presented with seizures, myoclonus, and memory problems. This is a relatively newly discovered and rare problem; however, it can be quite debilitating if left untreated. This diagnosis may be often missed due to the absence of highly sensitive tests. Autoimmune encephalitis has to be on the list of differential diagnoses for patients with new-onset psychiatric or neurological symptoms.
我们描述了一例患有卵巢畸胎瘤的女性因副肿瘤综合征而引发的可能的自身免疫性脑炎病例。患者可能会出现精神和神经症状,这些症状是由抗N-甲基-D-天冬氨酸(抗NMDA)受体抗体引起的,该抗体是机体对穿过血脑屏障并损害边缘区脑组织的畸胎瘤产生的反应,进而引发脑炎。我们的患者出现了癫痫发作、肌阵挛和记忆问题。这是一个相对新发现的罕见问题;然而,如果不治疗,它可能会使人相当虚弱。由于缺乏高灵敏度的检测方法,这种诊断常常会被漏诊。自身免疫性脑炎必须列入新发精神或神经症状患者的鉴别诊断清单中。