潜在的抗肿瘤药物：5-氟尿嘧啶-烟酰胺共晶体。
Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide.
作者信息
Zhang Zhuyan, Yu Nan, Xue Chang, Gao Shan, Deng Zhaopeng, Li Min, Liu Cong, Castellot John, Han Siying
机构信息
Pharmaceutical Experiment Teaching Center, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China.
出版信息
ACS Omega. 2020 Jun 24;5(26):15777-15782. doi: 10.1021/acsomega.9b03574. eCollection 2020 Jul 7.
5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil-water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug.
5-氟尿嘧啶-烟酰胺（5-FU-NCM）是一种通过氢键形成二维层状结构的共晶体，在室温下通过溶剂蒸发和液相辅助研磨合成。与单独的5-氟尿嘧啶相比，溶解度、油水分配系数、体内外抗肿瘤效果、急性毒性和药代动力学参数的结果表明，该共晶体是一种潜在的抗肿瘤药物。
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