Department of Clinical, Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
Cancer Center Amsterdam (CCA), Amsterdam UMC, Amsterdam, The Netherlands.
J Cancer Surviv. 2021 Feb;15(1):77-86. doi: 10.1007/s11764-020-00912-9. Epub 2020 Jul 12.
The eHealth self-management application 'Oncokompas' was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, and obtaining personalized feedback and options for supportive care. The aim of this study was to assess the cost-utility of Oncokompas compared with care as usual (CAU) among cancer survivors.
Survivors were randomly allocated to the intervention or control group. Direct (non-)medical, indirect non-medical costs, and HRQOL were measured at 3- and 6-month follow-up, using iMTA Medical Consumption and Productivity Costs and the EuroQol-5D questionnaires. Mean cumulative costs and quality-adjusted life-years (QALYs) were compared between both groups.
In total, 625 survivors were randomized into intervention (n = 320) or control group (n = 305). Base case analysis showed that incremental costs from a societal perspective were - €163 (95% CI, - 665 to 326), and incremental QALYs were 0.0017 (95% CI, - 0.0121 to 0.0155) in the intervention group compared with those in the control group. The probability that, compared with CAU, Oncokompas is more effective was 60%, less costly 73%, and both more effective and less costly 47%. Sensitivity analyses showed that incremental costs vary between - €40 and €69, and incremental QALYs vary between - 0.0023 and - 0.0057.
Oncokompas is likely to be equally effective on utilities, and not more expensive than CAU, and will therefore contribute to sustainable cancer survivorship care in a (cost-)effective manner.
Oncokompas seems to improve HRQOL and reduces the burden of several tumour-specific symptoms, while costs from a societal perspective are similar to CAU.
电子健康自我管理应用程序“Oncokompas”旨在支持癌症幸存者监测健康相关生活质量(HRQOL)和症状,并获得个性化的支持性护理反馈和选择。本研究的目的是评估 Oncokompas 与癌症幸存者的常规护理(CAU)相比的成本效用。
幸存者被随机分配到干预组或对照组。在 3 个月和 6 个月的随访中,使用 iMTA 医疗消费和生产力成本以及 EuroQol-5D 问卷测量直接(非)医疗、间接非医疗成本和 HRQOL。比较两组之间的平均累积成本和质量调整生命年(QALYs)。
共有 625 名幸存者被随机分配到干预组(n=320)或对照组(n=305)。基于病例分析显示,从社会角度来看,干预组的增量成本为-€163(95%CI,-€665 至 326),与对照组相比,干预组的增量 QALYs 为 0.0017(95%CI,-€0.0121 至 0.0155)。与 CAU 相比,Oncokompas 更有效的概率为 60%,更便宜的概率为 73%,同时更有效和更便宜的概率为 47%。敏感性分析表明,增量成本在-€40 至 €69 之间变化,增量 QALYs 在-€0.0023 至-€0.0057 之间变化。
Oncokompas 在效用上可能同样有效,并且不会比 CAU 更昂贵,因此将以(成本)有效的方式为可持续的癌症生存护理做出贡献。
Oncokompas 似乎可以提高 HRQOL,并减轻多种肿瘤特异性症状的负担,而从社会角度来看,成本与 CAU 相似。